Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Aquifex aeolicus VF5 Enzyme: dihydroorotate dehydrogenase 1B

Gene: pyrD Accession Numbers: GJBH-36 (Aaeo224324Cyc), aq_046

Summary:
catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits

Locations: cytoplasm

Map Position: [29,251 -> 30,171] (1.89 centisomes) on NC_000918 chromosome
Length: 921 bp / 306 aa

Molecular Weight of Polypeptide: 33.523 kD (from nucleotide sequence)

Unification Links: Entrez-gene:1192658 , Entrez:15605646 , NCBI-Protein:NP_213021.1 , UniProt:NP_213021.1

Gene-Reaction Schematic: ?

Gene Class: UNCLASSIFIED


Enzymatic reaction of: dihydroorotate dehydrogenase

Synonyms: DHOD, L-4,5-dihydroorotate:oxygen reductase, (S)-dihydroorotate:oxygen oxidoreductase, dihydroorotate oxidase

EC Number: 1.3.5.2

In Pathways: superpathway of pyrimidine ribonucleotides de novo biosynthesis , UMP biosynthesis


Enzymatic reaction of: dihydroorotate dehydrogenase 1B

EC Number: 1.3.1.14

(S)-dihydroorotate + NAD+ <=> orotate + NADH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Reversibility of this reaction is unspecified.


Gene Local Context (not to scale): ?

Transcription Unit:

Notes:


References

Green04: Green ML, Karp PD (2004). "A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases." BMC Bioinformatics 5;76. PMID: 15189570


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Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13A.