Aquifex aeolicus VF5 Enzyme: dihydroorotate dehydrogenase 1B

Gene: pyrD Accession Numbers: GJBH-36 (Aaeo224324Cyc), aq_046

catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits

Locations: cytoplasm

Map Position: [29,251 -> 30,171] (1.89 centisomes, 7°) on NC_000918 chromosome
Length: 921 bp / 306 aa

Molecular Weight of Polypeptide: 33.523 kD (from nucleotide sequence)

Unification Links: Entrez-gene:1192658 , Entrez:15605646 , NCBI-Protein:NP_213021.1 , UniProt:NP_213021.1

Gene-Reaction Schematic: ?

Gene-Reaction Schematic


Enzymatic reaction of: dihydroorotate dehydrogenase

Synonyms: DHOD, L-4,5-dihydroorotate:oxygen reductase, (S)-dihydroorotate:oxygen oxidoreductase, dihydroorotate oxidase

EC Number:

Transport reaction diagram for dihydroorotate dehydrogenase

In Pathways: superpathway of pyrimidine ribonucleotides de novo biosynthesis , UMP biosynthesis

Enzymatic reaction of: dihydroorotate dehydrogenase 1B

EC Number:

(S)-dihydroorotate + NAD+ <=> orotate + NADH + H+

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Reversibility of this reaction is unspecified.

Gene Local Context (not to scale): ?

Gene local context diagram

Transcription Unit:

Transcription-unit diagram



Green04: Green ML, Karp PD (2004). "A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases." BMC Bioinformatics 5;76. PMID: 15189570

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