Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Aquifex aeolicus VF5 Reaction: 2.7.4.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.4.6

Enzymes and Genes:
nucleoside diphosphate kinase : ndk

In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis III , pyrimidine deoxyribonucleotide phosphorylation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside-diphosphate kinase

Enzyme Commission Synonyms: nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphokinase, nucleotide phosphate kinase, UDP kinase, uridine diphosphate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 94.98999 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.

Citations: [Berg54, Ayengar56, Kirkland59, Krebs53, Nakamura66, Ratliff64]

Gene-Reaction Schematic: ?

Instance reactions of [a nucleoside diphosphate + ATP = a nucleoside triphosphate + ADP] (2.7.4.6):
i1: ATP + IDP = ITP + ADP (2.7.4.6)

i2: dGDP + ATP → dGTP + ADP (2.7.4.6)

i3: ATP + dIDP = ADP + dITP (2.7.4.6)

i4: dADP + ATP → dATP + ADP (2.7.4.6)

i5: dTDP + ATP → dTTP + ADP (2.7.4.6)

i6: GDP + ATP → GTP + ADP (2.7.4.6)

i7: dCDP + ATP → dCTP + ADP (2.7.4.6)
i8: dUDP + ATP → dUTP + ADP (2.7.4.6)

i9: UDP + ATP → UTP + ADP (2.7.4.6)

i10: CDP + ATP → CTP + ADP (2.7.4.6)

Relationship Links: BRENDA:EC:2.7.4.6 , ENZYME:EC:2.7.4.6 , IUBMB-ExplorEnz:EC:2.7.4.6

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Ayengar56: Ayengar P, Gibson DM, Sanadi DR (1956). "Transphosphorylations between nucleoside phosphates." Biochim Biophys Acta 21(1);86-91. PMID: 13363863

Berg54: Berg P, Joklik WK (1954). "Enzymatic phosphorylation of nucleoside diphosphates." J Biol Chem 210(2);657-72. PMID: 13211603

Kirkland59: Kirkland RJ, Turner JF (1959). "Nucleoside diphosphokinase of pea seeds." Biochem J 72;716-20. PMID: 14409347

Krebs53: Krebs HA, Hems R (1953). "Some reactions of adenosine and inosine phosphates in animal tissues." Biochim Biophys Acta 12(1-2);172-80. PMID: 13115426

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakamura66: Nakamura H, Sugino Y (1966). "Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus." J Biol Chem 241(21);4917-22. PMID: 5925862

Ratliff64: Ratliff RL, Weaver RH, LardyHA, Kuby SA (1964). "Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast." J Biol Chem 239;301-9. PMID: 14114857


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