Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Aquifex aeolicus VF5 Reaction: 2.7.4.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.4.6

Enzymes and Genes:
nucleoside diphosphate kinase : ndk

In Pathway: purine deoxyribonucleosides salvage , guanosine deoxyribonucleotides de novo biosynthesis I , guanosine deoxyribonucleotides de novo biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside-diphosphate kinase

Enzyme Commission Synonyms: nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphokinase, nucleotide phosphate kinase, UDP kinase, uridine diphosphate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 94.98999 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.

Citations: [Berg54, Ayengar56, Kirkland59, Krebs53, Nakamura66, Ratliff64]

Gene-Reaction Schematic: ?

Instance reactions of [a nucleoside diphosphate + ATP = a nucleoside triphosphate + ADP] (2.7.4.6):
i1: dCDP + ATP → dCTP + ADP (2.7.4.6)

i2: dUDP + ATP → dUTP + ADP (2.7.4.6)

i3: GDP + ATP → GTP + ADP (2.7.4.6)

i4: UDP + ATP → UTP + ADP (2.7.4.6)

i5: CDP + ATP → CTP + ADP (2.7.4.6)

i6: ATP + dIDP = ADP + dITP (2.7.4.6)

i7: dADP + ATP → dATP + ADP (2.7.4.6)

i8: dGDP + ATP → dGTP + ADP (2.7.4.6)
i9: ATP + IDP = ITP + ADP (2.7.4.6)

i10: dTDP + ATP → dTTP + ADP (2.7.4.6)

Relationship Links: BRENDA:EC:2.7.4.6 , ENZYME:EC:2.7.4.6 , IUBMB-ExplorEnz:EC:2.7.4.6

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Ayengar56: Ayengar P, Gibson DM, Sanadi DR (1956). "Transphosphorylations between nucleoside phosphates." Biochim Biophys Acta 21(1);86-91. PMID: 13363863

Berg54: Berg P, Joklik WK (1954). "Enzymatic phosphorylation of nucleoside diphosphates." J Biol Chem 210(2);657-72. PMID: 13211603

Kirkland59: Kirkland RJ, Turner JF (1959). "Nucleoside diphosphokinase of pea seeds." Biochem J 72;716-20. PMID: 14409347

Krebs53: Krebs HA, Hems R (1953). "Some reactions of adenosine and inosine phosphates in animal tissues." Biochim Biophys Acta 12(1-2);172-80. PMID: 13115426

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakamura66: Nakamura H, Sugino Y (1966). "Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus." J Biol Chem 241(21);4917-22. PMID: 5925862

Ratliff64: Ratliff RL, Weaver RH, LardyHA, Kuby SA (1964). "Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast." J Biol Chem 239;301-9. PMID: 14114857


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