Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Aquifex aeolicus VF5 Reaction: 2.7.7.24

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.7.24

Enzymes and Genes:
glucose-1-phosphate thymidylyltransferase : spsI

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucose-1-phosphate thymidylyltransferase

Enzyme Commission Synonyms: glucose 1-phosphate thymidylyltransferase, dTDP-glucose synthase, dTDP-glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, TDP-glucose pyrophosphorylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -103.30353 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in the biosynthesis of L-rhamnose in bacteria.

Citations: [PAZUR61, KORNFELD61, Zuccotti01]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.7.24 , ENZYME:EC:2.7.7.24 , IUBMB-ExplorEnz:EC:2.7.7.24

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

KORNFELD61: KORNFELD S, GLASER L (1961). "The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose." J Biol Chem 236;1791-4. PMID: 13753209

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

PAZUR61: PAZUR JH, SHUEY EW (1961). "The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose." J Biol Chem 236;1780-5. PMID: 13733719

Zuccotti01: Zuccotti S, Zanardi D, Rosano C, Sturla L, Tonetti M, Bolognesi M (2001). "Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase." J Mol Biol 313(4);831-43. PMID: 11697907


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Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.