Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
glucose-1-phosphate thymidylyltransferase: spsI

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucose-1-phosphate thymidylyltransferase

Enzyme Commission Synonyms: glucose 1-phosphate thymidylyltransferase, dTDP-glucose synthase, dTDP-glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, TDP-glucose pyrophosphorylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -103.30353Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in the biosynthesis of L-rhamnose in bacteria.

Citations: [PAZUR61, KORNFELD61, Zuccotti01]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


KORNFELD61: KORNFELD S, GLASER L (1961). "The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose." J Biol Chem 236;1791-4. PMID: 13753209

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

PAZUR61: PAZUR JH, SHUEY EW (1961). "The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose." J Biol Chem 236;1780-5. PMID: 13733719

Zuccotti01: Zuccotti S, Zanardi D, Rosano C, Sturla L, Tonetti M, Bolognesi M (2001). "Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase." J Mol Biol 313(4);831-43. PMID: 11697907

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