Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATPInferred by computational analysis: hisIE

In Pathway: histidine biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoribosyl-ATP diphosphatase

Enzyme Commission Synonyms: phosphoribosyl-ATP pyrophosphatase, phosphoribosyladenosine triphosphate pyrophosphatase, 1-(5-phosphoribosyl)-ATP diphosphohydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -124.32709Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The Neurospora crassa enzyme also catalyses the reactions of EC (histidinol dehydrogenase) and EC (phosphoribosyl-AMP cyclohydrolase).

Citations: [Smith65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Smith65: Smith DW, Ames BN (1965). "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis." J Biol Chem 240;3056-63. PMID: 14342333

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