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Aquifex aeolicus VF5 Reaction: 3.6.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.1.1

Enzymes and Genes:
inorganic pyrophosphatase : ppa

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inorganic diphosphatase

Enzyme Commission Synonyms: Diphosphate phosphohydrolase, Pyrophosphate phosphohydrolase, Inorganic diphosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 4.1469727 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.

Citations: [Bailey44, KUNITZ52, RAFTER60]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.6.1.1 , ENZYME:EC:3.6.1.1 , IUBMB-ExplorEnz:EC:3.6.1.1

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Bailey44: Bailey K, Webb EC (1944). "Purification and properties of yeast pyrophosphatase." Biochem J 38(5);394-8. PMID: 16747821

KUNITZ52: KUNITZ M (1952). "Crystalline inorganic pyrophosphatase isolated from baker's yeast." J Gen Physiol 35(3);423-50. PMID: 14898026

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

RAFTER60: RAFTER GW (1960). "Pyrophosphate metabolism in liver mitochondria." J Biol Chem 235;2475-7. PMID: 14435825


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