Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

In Pathway: methylerythritol phosphate pathway

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: isopentenyl-diphosphate Δ-isomerase

Enzyme Commission Synonyms: isopentenylpyrophosphate δ-isomerase, methylbutenylpyrophosphate isomerase, isopentenylpyrophosphate isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.66 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Streptomyces sp. CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity.

Citations: [Kaneda01, Bishop83, AGRANOFF60]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


AGRANOFF60: AGRANOFF BW, EGGERER H, HENNING U, LYNEN F (1960). "Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase." J Biol Chem 235;326-32. PMID: 13792054

Bishop83: Bishop JM (1983). "Cellular oncogenes and retroviruses." Annu Rev Biochem 52;301-54. PMID: 6351725

Kaneda01: Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001). "An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190." Proc Natl Acad Sci U S A 98(3);932-7. PMID: 11158573

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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