|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: methylerythritol phosphate pathway
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: isopentenyl-diphosphate Δ-isomerase
Enzyme Commission Synonyms: isopentenylpyrophosphate δ-isomerase, methylbutenylpyrophosphate isomerase, isopentenylpyrophosphate isomerase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 0.66 [Latendresse13]
Enzyme Commission Summary:
The enzyme from Streptomyces sp. CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity.
Kaneda01: Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001). "An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190." Proc Natl Acad Sci U S A 98(3);932-7. PMID: 11158573
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