Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
methylenetetrahydrofolate dehydrogenase Inferred by computational analysis : folD

In Pathway: reductive acetyl coenzyme A pathway , formylTHF biosynthesis , folate transformations I , tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methenyltetrahydrofolate cyclohydrolase

Enzyme Commission Synonyms: Citrovorum factor cyclodehydrase, cyclohydrolase, formyl-methenyl-methylenetetrahydrofolate synθse (combined)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.2422333 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) (EC and formatetetrahydrofolate ligase (EC activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC activity or formimidoyltetrahydrofolate cyclodeaminase (EC activity.

This reaction is involved in folic acid synthesis and is necessary for the biosynthesis of purines, thymydylate, methionine, histidine, pantothenate and formyl tRNA-MET.

Citations: [Rabinowitz56, TABOR59]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rabinowitz56: Rabinowitz, J.C., Pricer, W.E. (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation." J. Am. Chem. Soc.

TABOR59: TABOR H, WYNGARDEN L (1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid." J Biol Chem 234(7);1830-46. PMID: 13672973

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