Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
methylenetetrahydrofolate dehydrogenaseInferred by computational analysis: folD

In Pathway: reductive acetyl coenzyme A pathway, formylTHF biosynthesis, folate transformations I, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methenyltetrahydrofolate cyclohydrolase

Enzyme Commission Synonyms: Citrovorum factor cyclodehydrase, cyclohydrolase, formyl-methenyl-methylenetetrahydrofolate synthetase (combined)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.2422333Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) ( EC and formatetetrahydrofolate ligase ( EC activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase ( EC activity or formimidoyltetrahydrofolate cyclodeaminase ( EC activity.

This reaction is involved in folic acid synthesis and is necessary for the biosynthesis of purines, thymydylate, methionine, histidine, pantothenate and formyl tRNA-MET.

Citations: [Rabinowitz56, Tabor59]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rabinowitz56: Rabinowitz, J.C., Pricer, W.E. (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation." J. Am. Chem. Soc.

Tabor59: Tabor, H., Wyngarden, L. (1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid." J Biol Chem 234(7);1830-46. PMID: 13672973

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