Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions tRNA-Charging-Reactions

EC Number:

Enzymes and Genes:
methionyl-tRNA synthetase subunit beta : metG'
methionyl-tRNA synthetase subunit alpha : metG

In Pathway: tRNA charging

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: The left side is missing: Elongation-tRNAMet: 1 . The right side is missing: MET-tRNAs: 1

Enzyme Commission Primary Name: methionine—tRNA ligase

Enzyme Commission Synonyms: methionyl-tRNA synθse, methionyl-transfer ribonucleic acid synθse, methionyl-transfer ribonucleate synθse, methionyl-transfer RNA synθse, methionine translase, MetRS

Enzyme Commission Summary:
In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC, methionyl-tRNA formyltransferase.

Citations: [Lee92]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


Lee92: Lee CP, Dyson MR, Mandal N, Varshney U, Bahramian B, RajBhandary UL (1992). "Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase." Proc Natl Acad Sci U S A 89(19);9262-6. PMID: 1409632

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