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Aquifex aeolicus VF5 Reaction: 6.1.1.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions tRNA-Reactions tRNA-Charging-Reactions

EC Number: 6.1.1.10

Enzymes and Genes:
methionyl-tRNA synthetase subunit beta : metG'
methionyl-tRNA synthetase subunit alpha : metG

In Pathway: tRNA charging

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: The left side is missing: Elongation-tRNAMet: 1 . The right side is missing: MET-tRNAs: 1

Enzyme Commission Primary Name: methionine—tRNA ligase

Enzyme Commission Synonyms: methionyl-tRNA synθse, methionyl-transfer ribonucleic acid synθse, methionyl-transfer ribonucleate synθse, methionyl-transfer RNA synθse, methionine translase, MetRS

Enzyme Commission Summary:
In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC 2.1.2.9, methionyl-tRNA formyltransferase.

Citations: [Lee92a]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:6.1.1.10 , ENZYME:EC:6.1.1.10 , IUBMB-ExplorEnz:EC:6.1.1.10

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Lee92a: Lee CP, Dyson MR, Mandal N, Varshney U, Bahramian B, RajBhandary UL (1992). "Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase." Proc Natl Acad Sci U S A 89(19);9262-6. PMID: 1409632


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Page generated by SRI International Pathway Tools version 19.0 on Thu Sep 3, 2015, biocyc12.