|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Polynucleotide-Reactions → RNA-Reactions → tRNA-Reactions → tRNA-Charging-Reactions|
EC Number: 188.8.131.52
In Pathway: tRNA charging
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: methionine—tRNA ligase
Enzyme Commission Synonyms: methionyl-tRNA synθse, methionyl-transfer ribonucleic acid synθse, methionyl-transfer ribonucleate synθse, methionyl-transfer RNA synθse, methionine translase, MetRS
Enzyme Commission Summary:
In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC 184.108.40.206, methionyl-tRNA formyltransferase.
Lee92b: Lee CP, Dyson MR, Mandal N, Varshney U, Bahramian B, RajBhandary UL (1992). "Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase." Proc Natl Acad Sci U S A 89(19);9262-6. PMID: 1409632
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