Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis III

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside-triphosphate phosphatase

Enzyme Commission Synonyms: nucleoside-triphosphatase, nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, nucleoside 5-triphosphatase, unspecific diphosphate phosphohydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -102.58887Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also hydrolyses other nucleoside triphosphates, diphosphates, thiamine diphosphate and FAD.

Citations: [Matsushita68, Lewis65, Brightwell68, Tong93, Hsieh96, Klinger03, Placzek07]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created in MetaCyc 28-Feb-2011 by Zhang P, TAIR
Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Brightwell68: Brightwell R, Tappel AL (1968). "Lysosomal acid pyrophosphatase and acid phosphatase." Arch Biochem Biophys 124(1);333-43. PMID: 5661608

Hsieh96: Hsieh HL, Tong CG, Thomas C, Roux SJ (1996). "Light-modulated abundance of an mRNA encoding a calmodulin-regulated, chromatin-associated NTPase in pea." Plant Mol Biol 30(1);135-47. PMID: 8616230

Klinger03: Klinger C, Rossbach M, Howe R, Kaufmann M (2003). "Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase." BMC Biochem 4;12. PMID: 14503925

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lewis65: Lewis M, Weissman S (1965). "Properties of a soluble nucleoside triphosphatase activity in mammalian liver." Arch Biochem Biophys 109;490-8. PMID: 14320490

Matsushita68: Matsushita S, Raacke ID (1968). "Purification of nucleoside triphosphatases from pea seedling ribosomes." Biochim Biophys Acta 166(3);707-10. PMID: 4301913

Placzek07: Placzek WJ, Almeida MS, Wuthrich K (2007). "NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase." J Mol Biol 367(3);788-801. PMID: 17291528

Tong93: Tong CG, Dauwalder M, Clawson GA, Hatem CL, Roux SJ (1993). "The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins." Plant Physiol 101(3);1005-11. PMID: 7508630

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