Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

In Pathway: reductive TCA cycle II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2-oxoglutarate carboxylase

Enzyme Commission Synonyms: oxalosuccinate synthetase, carboxylating factor for ICDH (incorrect), CFI, OGC

Standard Gibbs Free Energy (ΔrG in kcal/mol): -9.341309Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [Aoshima04] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC, isocitrate dehydrogenase (NAD+), but this has since been disproved [Aoshima06]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC [Aoshima06].

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised in MetaCyc 14-Dec-2011 by Caspi R, SRI International
Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Aoshima04: Aoshima M, Ishii M, Igarashi Y (2004). "A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6." Mol Microbiol 51(3);791-8. PMID: 14731279

Aoshima06: Aoshima M, Igarashi Y (2006). "A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6." Mol Microbiol 62(3);748-59. PMID: 17076668

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC14B.