|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: reductive TCA cycle II
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 2-oxoglutarate carboxylase
Enzyme Commission Synonyms: oxalosuccinate synthetase, carboxylating factor for ICDH (incorrect), CFI, OGC
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -9.341309 [Latendresse13]
Enzyme Commission Summary:
A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [Aoshima04] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 22.214.171.124, isocitrate dehydrogenase (NAD+), but this has since been disproved [Aoshima06]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 126.96.36.199 [Aoshima06].
Aoshima04: Aoshima M, Ishii M, Igarashi Y (2004). "A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6." Mol Microbiol 51(3);791-8. PMID: 14731279
Aoshima06: Aoshima M, Igarashi Y (2006). "A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6." Mol Microbiol 62(3);748-59. PMID: 17076668
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