Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Aquifex aeolicus VF5 Reaction: 3.2.2.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.2.2.1

In Pathway: guanine and guanosine salvage II

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: purine nucleosidase

Enzyme Commission Synonyms: nucleosidase (misleading), purine β-ribosidase, purine nucleoside hydrolase, purine ribonucleosidase, ribonucleoside hydrolase (misleading), nucleoside hydrolase (misleading), N-ribosyl purine ribohydrolase, nucleosidase g, N-D-ribosylpurine ribohydrolase, inosine-adenosine-guanosine preferring nucleoside hydrolase, purine-specific nucleoside N-ribohydrolase, IAG-nucleoside hydrolase, IAG-NH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.73301315 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from the bacterium Ochrobactrum anthropi specifically catalyses the irreversible N-riboside hydrolysis of purine nucleosides. Pyrimidine nucleosides, purine and pyrimidine nucleotides, NAD+, NADP+ and nicotinaminde mononucleotide are not substrates [Ogawa01].

Citations: [MazumderShivaku05, Versees02, Heppel52, Takagi57, TARR55, Parkin96]

Relationship Links: BRENDA:EC:3.2.2.1 , ENZYME:EC:3.2.2.1 , IUBMB-ExplorEnz:EC:3.2.2.1

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Heppel52: Heppel LA, Hilmoe RJ (1952). "[Phosphorolysis and hydrolysis of purine ribosides by enzymes from yeast]." J Biol Chem 198(2);683-94. PMID: 12999785

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MazumderShivaku05: Mazumder-Shivakumar D, Bruice TC (2005). "Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues." Biochemistry 44(21);7805-17. PMID: 15909995

Ogawa01: Ogawa J, Takeda S, Xie SX, Hatanaka H, Ashikari T, Amachi T, Shimizu S (2001). "Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi." Appl Environ Microbiol 67(4);1783-7. PMID: 11282633

Parkin96: Parkin DW (1996). "Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism." J Biol Chem 271(36);21713-9. PMID: 8702965

Takagi57: Takagi Y, Horecker BL (1957). "Purification and properties of a bacterial riboside hydrolase." J Biol Chem 225(1);77-86. PMID: 13416219

TARR55: TARR HL (1955). "Fish muscle riboside hydrolases." Biochem J 59(3);386-91. PMID: 14363106

Versees02: Versees W, Decanniere K, Van Holsbeke E, Devroede N, Steyaert J (2002). "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax." J Biol Chem 277(18);15938-46. PMID: 11854281


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