Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Aquifex aeolicus VF5 Reaction: 3.2.2.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.2.2.1

In Pathway: guanine and guanosine salvage II

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number.

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: purine nucleosidase

Enzyme Commission Synonyms: nucleosidase (misleading), purine β-ribosidase, purine nucleoside hydrolase, purine ribonucleosidase, ribonucleoside hydrolase (misleading), nucleoside hydrolase (misleading), N-ribosyl purine ribohydrolase, nucleosidase g, N-D-ribosylpurine ribohydrolase, inosine-adenosine-guanosine preferring nucleoside hydrolase, purine-specific nucleoside N-ribohydrolase, IAG-nucleoside hydrolase, IAG-NH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.73301315 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from the bacterium Ochrobactrum anthropi specifically catalyses the irreversible N-riboside hydrolysis of purine nucleosides. Pyrimidine nucleosides, purine and pyrimidine nucleotides, NAD+, NADP+ and nicotinaminde mononucleotide are not substrates [Ogawa01].

Citations: [MazumderShivaku05, Versees02, HEPPEL52, TAKAGI57, TARR55, Parkin96]

Relationship Links: BRENDA:EC:3.2.2.1 , ENZYME:EC:3.2.2.1 , IUBMB-ExplorEnz:EC:3.2.2.1

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

HEPPEL52: HEPPEL LA, HILMOE RJ (1952). "[Phosphorolysis and hydrolysis of purine ribosides by enzymes from yeast]." J Biol Chem 198(2);683-94. PMID: 12999785

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MazumderShivaku05: Mazumder-Shivakumar D, Bruice TC (2005). "Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues." Biochemistry 44(21);7805-17. PMID: 15909995

Ogawa01: Ogawa J, Takeda S, Xie SX, Hatanaka H, Ashikari T, Amachi T, Shimizu S (2001). "Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi." Appl Environ Microbiol 67(4);1783-7. PMID: 11282633

Parkin96: Parkin DW (1996). "Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism." J Biol Chem 271(36);21713-9. PMID: 8702965

TAKAGI57: TAKAGI Y, HORECKER BL (1957). "Purification and properties of a bacterial riboside hydrolase." J Biol Chem 225(1);77-86. PMID: 13416219

TARR55: TARR HL (1955). "Fish muscle riboside hydrolases." Biochem J 59(3);386-91. PMID: 14363106

Versees02: Versees W, Decanniere K, Van Holsbeke E, Devroede N, Steyaert J (2002). "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax." J Biol Chem 277(18);15938-46. PMID: 11854281


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