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Aquifex aeolicus VF5 Reaction: 2.7.1.130

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.130

Enzymes and Genes:
hypothetical protein Inferred by computational analysis : aq_1656

In Pathway: lipid IVA biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tetraacyldisaccharide 4′-kinase

Enzyme Commission Synonyms: lipid-A 4'-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -17.31247 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved with EC 2.3.1.129, acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase, and EC 2.4.1.182, lipid-A-disaccharide synthase, in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Citations: [Ray87]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:2.7.1.130 , ENZYME:EC:2.7.1.130 , IUBMB-ExplorEnz:EC:2.7.1.130

Credits:
Imported from MetaCyc 08-Aug-2014 by Subhraveti P , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ray87: Ray BL, Raetz CR (1987). "The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A." J Biol Chem 262(3);1122-8. PMID: 3027079


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