Aquifex aeolicus VF5 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:
hypothetical proteinInferred by computational analysis: aq_1656

In Pathway: lipid IVA biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tetraacyldisaccharide 4′-kinase

Enzyme Commission Synonyms: lipid-A 4'-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -17.31247Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved with EC, acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase, and EC, lipid-A-disaccharide synthase, in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Citations: [Ray87a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Imported from MetaCyc 08-Aug-2014 by Subhraveti P, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ray87a: Ray BL, Raetz CR (1987). "The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A." J Biol Chem 1987;262(3);1122-8. PMID: 3027079

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