|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: lipid IVA biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: tetraacyldisaccharide 4′-kinase
Enzyme Commission Synonyms: lipid-A 4'-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -17.31247 [Latendresse13]
Enzyme Commission Summary:
Involved with EC 18.104.22.168 (acyl-[acyl-carrier- protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC 22.214.171.124 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
Ray87a: Ray BL, Raetz CR (1987). "The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A." J Biol Chem 262(3);1122-8. PMID: 3027079
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