|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: lipid IVA biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: tetraacyldisaccharide 4′-kinase
Enzyme Commission Synonyms: lipid-A 4'-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -17.31247 [Latendresse13]
Enzyme Commission Summary:
Involved with EC 184.108.40.206, acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase, and EC 220.127.116.11, lipid-A-disaccharide synthase, in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
Ray87a: Ray BL, Raetz CR (1987). "The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A." J Biol Chem 1987;262(3);1122-8. PMID: 3027079
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