|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: UTP and CTP de novo biosynthesis
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nucleoside-diphosphate kinase
Enzyme Commission Synonyms: nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphokinase, nucleotide phosphate kinase, UDP kinase, uridine diphosphate kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 94.98999 [Latendresse13]
Enzyme Commission Summary:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
Instance reactions of [a nucleoside diphosphate + ATP = a nucleoside triphosphate + ADP] (184.108.40.206):
i1: dUDP + ATP → dUTP + ADP (220.127.116.11)
i2: ATP + IDP = ITP + ADP (18.104.22.168)
i3: ATP + dIDP = ADP + dITP (22.214.171.124)
i4: GDP + ATP → GTP + ADP (126.96.36.199)
i5: CDP + ATP → CTP + ADP (188.8.131.52)
i6: UDP + ATP → UTP + ADP (184.108.40.206)
i7: dCDP + ATP → dCTP + ADP (220.127.116.11)
i8: dTDP + ATP → dTTP + ADP (18.104.22.168)
i9: dADP + ATP → dATP + ADP (22.214.171.124)
i10: dGDP + ATP → dGTP + ADP (126.96.36.199)
Nakamura66: Nakamura H, Sugino Y (1966). "Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus." J Biol Chem 241(21);4917-22. PMID: 5925862
Ratliff64: Ratliff RL, Weaver RH, LardyHA, Kuby SA (1964). "Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast." J Biol Chem 239;301-9. PMID: 14114857
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