Caulobacter crescentus CB15 Protein Class: a factor XI

Synonyms: plasma thromboplastin antecedent

Factor XI, or plasma thromboplastin antecedent, is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade EC Like many other coagulation factors, it is a serine protease.

Factor XI is produced by the liver and circulates as a homo-dimer in its inactive form. It is activated into factor XIa by thrombin (also known as factor XIIa), and it is also autocatalytic in that respect.

Factor XI activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds. Factor IXa, in turn, activates factor X.

Alternative forms of a factor XI: a factor XIa (summary available)

Unification Links: Wikipedia:Factor_XI

Created 10-Aug-2009 by SRI International

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Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, biocyc14.