Caulobacter crescentus CB15 Protein Class: a C5a anaphylatoxin

Superclasses: a modified protein
a polypeptide

Derived from proteolytic degradation of a complement C5 precursor, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Alternative forms of a C5a anaphylatoxin:
a complement 5 α chain
a complement C5 α' chain

Relationship Links: PDB:Structure:1CFA, PDB:Structure:1KJS, PDB:Structure:1XWE

Gene-Reaction Schematic

Gene-Reaction Schematic

Created 05-Feb-2007 by SRI International

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