Caulobacter crescentus CB15 Pathway: formylTHF biosynthesis I

Pathway diagram: formylTHF biosynthesis I

Note: a dashed line (without arrowheads) between two compound names is meant to imply that the two names are just different instantiations of the same compound -- i.e. one may be a specific name and the other a general name, or they may both represent the same compound in different stages of a polymerization-type pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Superclasses: Biosynthesis Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis Vitamins Biosynthesis Folate Biosynthesis

Pathway Summary from MetaCyc:
General Background

Folates are tripartite molecules comprising pterin, p-aminobenzoate (pABA), and glutamate moieties. In natural folates the pterin ring exists in the dihydro or tetrahydro state. Folate usually has a gamma-linked polyglutamyl tail of up to eight residues attached to the first glutamate. The one-carbon units (methyl or formyl) are either attached to the N-5 of the pterin moiety, to the N-10 of the pABA moiety or bridged in between these two (e.g., 5,10-methenyl or methylene-THF). 10-formyl-tetrahydrofolates are involved in tetrahydrofolate, purine and formate synthesis [Nagy95, deCrecyLagard07].

About This Pathway

The formation of the formyl and methyl derivatives of tetrahydrofolate (vitamin B9) directly involved in or representing sidesteps of the biosynthesis of this vital cofactor is displayed in this pathway. Conversion of 10-formyl-tetrahydrofolate to tetrahydrofolate occurs either directly through hydrolysis or via 5-methyl-tetrahydrofolate in several steps [Nagy95, deCrecyLagard07].

Variants: 4-aminobenzoate biosynthesis , folate polyglutamylation , folate transformations I , folate transformations II , superpathway of tetrahydrofolate biosynthesis , superpathway of tetrahydrofolate biosynthesis and salvage , tetrahydrofolate biosynthesis , tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate

Pathway Evidence Glyph:

Pathway evidence glyph

Key to pathway glyph edge colors: ?

  An enzyme catalyzing this reaction is present in this organism
  No enzyme catalyzing this reaction has been identified in this organism
  The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway

Created 07-Aug-1995 by Riley M , Marine Biological Laboratory
Reviewed 26-Feb-2010 by Sarker M


deCrecyLagard07: de Crecy-Lagard V, El Yacoubi B, de la Garza RD, Noiriel A, Hanson AD (2007). "Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations." BMC Genomics 8;245. PMID: 17645794

Nagy95: Nagy PL, Marolewski A, Benkovic SJ, Zalkin H (1995). "Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli." J Bacteriol 1995;177(5);1292-8. PMID: 7868604

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Green04: Green ML, Karp PD (2004). "A Bayesian method for identifying missing enzymes in predicted metabolic pathway databases." BMC Bioinformatics 5;76. PMID: 15189570

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Page generated by SRI International Pathway Tools version 19.0 on Wed Apr 1, 2015, biocyc13.