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Caulobacter crescentus CB15 Pathway: ammonia assimilation cycle III
Inferred by computational analysis


Pathway diagram: ammonia assimilation cycle III

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Synonyms: ammonia assimilation III, GS/GOGAT pathway

Superclasses: Degradation/Utilization/AssimilationInorganic Nutrients MetabolismNitrogen Compounds MetabolismAmmonia Assimilation
Superpathways

Pathway Summary from MetaCyc:
Escherichia coli K-12 can synthesize L-glutamate from ammonia in two pathways. In addition, if complex sources of nitrogen are available, other pathways become active and take over glutamate synthesis.

In the first pathway L-glutamate is synthesized directly from ammonia, 2-oxoglutarate, and NADPH, as described in L-glutamate biosynthesis III.

The other pathway, which is described here, is a cyclic pathway, which consists of two steps.

In the first step L-glutamine is synthesized from ammonia and L-glutamate in an ATP-requiring reaction.

ammonium + L-glutamate + ATP → L-glutamine + ADP + phosphate + H+ (EC 6.3.1.2)

In the second step the amido group is transferred from L-glutamine to 2-oxoglutarate yielding two molecules of L-glutamate.

2 L-glutamate + NADP+ ← L-glutamine + 2-oxoglutarate + NADPH + H+ (EC 1.4.1.13)

Because glutamine biosynthesis utilizes one molecule of glutamate and the second reaction yields 2 molecules of glutamate, these two reactions function as a cycle, each turn of which utilizes one molecule each of ammonia, ATP, NADPH, and 2-oxoglutarate, and produces one molecule of L-glutamate.

This pathway is active in energy-rich (glucose-containing), nitrogen-poor environments.

Subpathways: glutamate biosynthesis I, glutamine biosynthesis I

Credits:
Created in MetaCyc 02-Dec-1998 by Marine Biological Laboratory
Imported from MetaCyc 18-Sep-2013 by Fulcher CA, SRI International


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Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Feb 10, 2016, biocyc11.