Caulobacter crescentus CB15 Pathway: threonine biosynthesis from homoserine

Pathway diagram: threonine biosynthesis from homoserine

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Superclasses: Biosynthesis Amino Acids Biosynthesis Proteinogenic Amino Acids Biosynthesis L-threonine Biosynthesis

Pathway Summary from MetaCyc:
The pathway of synthesis of threonine from homoserine is a two-step pathway that converts homoserine to threonine by way of a phosphorylated intermediate.

The final product of this pathway, threonine, serves as a structural constituent of proteins and feeds into the biosynthetic pathway for isoleucine. The enzymes carrying out both steps in this pathway are regulated at the gene level by threonine- and isoleucine-dependent attenuation, as part of attenuation control of an operon that also includes a gene coding for an enzyme in the upstream pathway of homoserine biosynthesis.

Superpathways: isoleucine biosynthesis I

Created this pathway so that threonine biosynthesis could be changed to be a super-pathway of this plus homoserine biosynthesis.

Pathway Evidence Glyph:

Pathway evidence glyph

Key to pathway glyph edge colors: ?

  An enzyme catalyzing this reaction is present in this organism
  The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway

Last-Curated ? 09-May-2008 by SRI International

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Page generated by SRI International Pathway Tools version 19.0 on Sat May 23, 2015, BIOCYC13A.