If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
|Superclasses:||Biosynthesis → Amino Acids Biosynthesis → Other Amino Acid Biosynthesis|
Pathway Summary from MetaCyc:
The homoserine biosynthesis pathway is a three-step pathway that converts L-aspartate into homoserine. Two of the three enzymes that catalyze the first step in this pathway are bifunctional, also serving to catalyze the final step in the pathway.
The final product of this pathway, homoserine, feeds into biosynthetic pathways for both threonine and methionine. Fittingly, this pathway is regulated by the outputs of both of those pathways. metL is repressed by abundant methionine. thrA is regulated by threonine- and isoleucine-dependent attenuation, and both the aspartate kinase and homoserine dehydrogenase activities of ThrA are inhibited by threonine. The middle enzymatic activity, aspartate semialdehyde dehydrogenase, is subject to some form of repression by both methionine and threonine.
Superpathways: superpathway of methionine biosynthesis (by sulfhydrylation), isoleucine biosynthesis I, superpathway of methionine biosynthesis (transsulfuration), homoserine and methionine biosynthesis, superpathway of S-adenosyl-L-methionine biosynthesis
Pathway Evidence Glyph:
This organism is in the expected taxonomic range for this pathway.
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