Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Caulobacter crescentus CB15 Pathway: 3-oxoadipate degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Synonyms: β-ketoadipate degradation

Superclasses: Degradation/Utilization/Assimilation Carboxylates Degradation

Pathway Summary from MetaCyc:
A variety of aromatic compounds, including catechol and protocatechuate, can be degraded via the β-ketoadipate pathway, which is widely distributed among soil bacteria and fungi, even though its organization and regulation vary among species [Harwood96].

Once β-ketoadipate is formed, it is converted to succinyl-CoA and acetyl-CoA. In Pseudomonas putida, the enzymes involved in β-ketoadipate degradation (β-ketoadipate:succinyl-CoA transferase, and β-ketoadipyl CoA thiolase) are inducible by β-ketoadipate [Ornston66].

The genes that encode the regulatory proteins and the enzymes of this pathway in Pseudomonas putida are clustered into two distinct groups: pcaIJ [Parales93] are separate from pcaRKF [Chan79], while in Acinetobacter calcoaceticus the genes are arranged in a single cluster (pcaIJFBDKCHG), which is induced by protocatechuate (as reported in [Harwood94]).

Superpathways: catechol degradation III (ortho-cleavage pathway) , aromatic compounds degradation via β-ketoadipate

Pathway Evidence Glyph:

Key to pathway glyph edge colors: ?

  An enzyme catalyzing this reaction is present in this organism
  The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway

Credits:
Created 30-Nov-2004 by Caspi R , SRI International


References

Chan79: Chan WY, Seale TW, Shukla JB, Rennert OM (1979). "Polyamine conjugates and total polyamine concentrations in human amniotic fluid." Clin Chim Acta 91(3);233-41. PMID: 761399

Harwood94: Harwood CS, Nichols NN, Kim MK, Ditty JL, Parales RE (1994). "Identification of the pcaRKF gene cluster from Pseudomonas putida: involvement in chemotaxis, biodegradation, and transport of 4-hydroxybenzoate." J Bacteriol 176(21);6479-88. PMID: 7961399

Harwood96: Harwood CS, Parales RE (1996). "The beta-ketoadipate pathway and the biology of self-identity." Annu Rev Microbiol 50;553-90. PMID: 8905091

Ornston66: Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. IV. Regulation." J Biol Chem 241(16);3800-10. PMID: 5916393

Parales93: Parales RE, Harwood CS (1993). "Regulation of the pcaIJ genes for aromatic acid degradation in Pseudomonas putida." J Bacteriol 175(18);5829-38. PMID: 8376330


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Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc12.