If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
Synonyms: β-ketoadipate degradation
|Superclasses:||Degradation/Utilization/Assimilation → Carboxylates Degradation|
Pathway Summary from MetaCyc:
A variety of aromatic compounds, including catechol and protocatechuate, can be degraded via the β-ketoadipate pathway, which is widely distributed among soil bacteria and fungi, even though its organization and regulation vary among species [Harwood96a].
Once β-ketoadipate is formed, it is converted to succinyl-CoA and acetyl-CoA. In Pseudomonas putida, the enzymes involved in β-ketoadipate degradation (β-ketoadipate:succinyl-CoA transferase, and β-ketoadipyl CoA thiolase) are inducible by β-ketoadipate [Ornston66b].
The genes that encode the regulatory proteins and the enzymes of this pathway in Pseudomonas putida are clustered into two distinct groups: pcaIJ [Parales93] are separate from pcaRKF [Chan79], while in Acinetobacter calcoaceticus the genes are arranged in a single cluster (pcaIJFBDKCHG), which is induced by protocatechuate (as reported in [Harwood94]).
Pathway Evidence Glyph:
Harwood94: Harwood CS, Nichols NN, Kim MK, Ditty JL, Parales RE (1994). "Identification of the pcaRKF gene cluster from Pseudomonas putida: involvement in chemotaxis, biodegradation, and transport of 4-hydroxybenzoate." J Bacteriol 176(21);6479-88. PMID: 7961399
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