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Caulobacter crescentus CB15 Pathway: 3-oxoadipate degradation

Pathway diagram: 3-oxoadipate degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Synonyms: β-ketoadipate degradation

Superclasses: Degradation/Utilization/Assimilation Carboxylates Degradation

Pathway Summary from MetaCyc:
A variety of aromatic compounds, including catechol and protocatechuate, can be degraded via the β-ketoadipate pathway, which is widely distributed among soil bacteria and fungi, even though its organization and regulation vary among species [Harwood96].

Once β-ketoadipate is formed, it is converted to succinyl-CoA and acetyl-CoA. In Pseudomonas putida, the enzymes involved in β-ketoadipate degradation (β-ketoadipate:succinyl-CoA transferase, and β-ketoadipyl CoA thiolase) are inducible by β-ketoadipate [Ornston66].

The genes that encode the regulatory proteins and the enzymes of this pathway in Pseudomonas putida are clustered into two distinct groups: pcaIJ [Parales93] are separate from pcaRKF [Chan79], while in Acinetobacter calcoaceticus the genes are arranged in a single cluster (pcaIJFBDKCHG), which is induced by protocatechuate (as reported in [Harwood94]).

Superpathways: catechol degradation III (ortho-cleavage pathway) , aromatic compounds degradation via β-ketoadipate

Pathway Evidence Glyph:

Pathway evidence glyph

Key to pathway glyph edge colors: ?

  An enzyme catalyzing this reaction is present in this organism
  The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway

Credits:
Created 30-Nov-2004 by SRI International


References

Chan79: Chan WY, Seale TW, Shukla JB, Rennert OM (1979). "Polyamine conjugates and total polyamine concentrations in human amniotic fluid." Clin Chim Acta 91(3);233-41. PMID: 761399

Harwood94: Harwood CS, Nichols NN, Kim MK, Ditty JL, Parales RE (1994). "Identification of the pcaRKF gene cluster from Pseudomonas putida: involvement in chemotaxis, biodegradation, and transport of 4-hydroxybenzoate." J Bacteriol 176(21);6479-88. PMID: 7961399

Harwood96: Harwood CS, Parales RE (1996). "The beta-ketoadipate pathway and the biology of self-identity." Annu Rev Microbiol 50;553-90. PMID: 8905091

Ornston66: Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. IV. Regulation." J Biol Chem 241(16);3800-10. PMID: 5916393

Parales93: Parales RE, Harwood CS (1993). "Regulation of the pcaIJ genes for aromatic acid degradation in Pseudomonas putida." J Bacteriol 175(18);5829-38. PMID: 8376330


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Page generated by SRI International Pathway Tools version 19.0 on Sat Mar 28, 2015, BIOCYC14B.