Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Caulobacter crescentus CB15 Pathway: aromatic compounds degradation via β-ketoadipate

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Synonyms: β-ketoadipate pathway

Superclasses: Degradation/Utilization/Assimilation Aromatic Compounds Degradation Catechol Degradation
Superpathways

Summary:
The intermediate role of 3-oxoadipate in the oxidative metabolism of aromatic compounds by bacteria was first suggested by Kilby, who reported its accumulation in cultures of Moraxella growing on phenol [Kilby48]. This observation was confirmed by the demonstration that cell-free extracts of Pseudomonas putida, induced by growth on aromatic precursors, can convert both catechol or protocatechuate to 3-oxoadipate [Stanier50].

The pathway is widely distributed among bacteria [Stanier73]. It consists of two parallel branches for the dissimilation of protocatechuate and catechol. While the enzymes of the pathway from different microorganisms share common ancestry [Patel73, Parke73, Patel74a], many different gene organizations and forms of regulation have evolved [Parales92].

Subpathways: catechol degradation to β-ketoadipate , 3-oxoadipate degradation , protocatechuate degradation II (ortho-cleavage pathway)

Variants: catechol degradation III (ortho-cleavage pathway)

Credits:
Created in MetaCyc 13-Dec-2006 by Caspi R , SRI International
Imported from MetaCyc 18-Sep-2013 by Fulcher CA , SRI International


References

Kilby48: Kilby, B. A., (1948). "The bacterial oxidation of phenol to β-ketoadipic acid." Biochem. J., 43, Proc. Biochem. Soc., v.

Parales92: Parales RE, Harwood CS (1992). "Characterization of the genes encoding beta-ketoadipate: succinyl-coenzyme A transferase in Pseudomonas putida." J Bacteriol 174(14);4657-66. PMID: 1624453

Parke73: Parke D, Meagher RB, Ornston LN (1973). "Relationships among enzymes of the beta-ketoadipate pathway. 3. Properties of crystalline gamma-carboxymuconolactone decarboxylase from Pseudomonas putida." Biochemistry 12(18);3537-42. PMID: 4199896

Patel73: Patel RN, Meagher RB, Ornston LN (1973). "Relationships among enzymes of the beta-ketoadipate pathway. II. Properties of crystalline beta-carboxy-cis,cis-muconate-lactonizing enzyme from Pseudomonas putida." Biochemistry 12(18);3531-7. PMID: 4199895

Patel74a: Patel RN, Meagher RB, Ornston LN (1974). "Relationships among enzymes of the beta-ketoadipate pathway. IV. Muconolactone isomerase from Acinetobacter calcoaceticus and Pseudomonas putida." J Biol Chem 249(23);7410-9. PMID: 4215816

Stanier50: Stanier, R.Y., Sleeper, B.P., Tsuchida, M., MacDonald, D.L. (1950). "The bacterial oxidation of aromatic compounds; III. The enzymatic oxidation of catechol and protocatechuic acid to beta-ketoadipic acid." J Bacteriol 59(2): 137-151. PMID: 15421941

Stanier73: Stanier RY, Ornston LN (1973). "The beta-ketoadipate pathway." Adv Microb Physiol 9(0);89-151. PMID: 4599397

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Lim02: Lim EK, Doucet CJ, Li Y, Elias L, Worrall D, Spencer SP, Ross J, Bowles DJ (2002). "The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates." J Biol Chem 277(1);586-92. PMID: 11641410


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Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc13.