If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
Synonyms: β-ketoadipate pathway
|Superclasses:||Degradation/Utilization/Assimilation → Aromatic Compounds Degradation → Catechol Degradation|
Pathway Summary from MetaCyc:
The intermediate role of 3-oxoadipate in the oxidative metabolism of aromatic compounds by bacteria was first suggested by Kilby, who reported its accumulation in cultures of Moraxella
The pathway is widely distributed among bacteria [Stanier73]. It consists of two parallel branches for the dissimilation of protocatechuate and catechol. While the enzymes of the pathway from different microorganisms share common ancestry [Patel73, Parke73, Patel74], many different gene organizations and forms of regulation have evolved [Parales92].
Parke73: Parke D, Meagher RB, Ornston LN (1973). "Relationships among enzymes of the beta-ketoadipate pathway. 3. Properties of crystalline gamma-carboxymuconolactone decarboxylase from Pseudomonas putida." Biochemistry 12(18);3537-42. PMID: 4199896
Patel73: Patel RN, Meagher RB, Ornston LN (1973). "Relationships among enzymes of the beta-ketoadipate pathway. II. Properties of crystalline beta-carboxy-cis,cis-muconate-lactonizing enzyme from Pseudomonas putida." Biochemistry 12(18);3531-7. PMID: 4199895
Patel74: Patel RN, Meagher RB, Ornston LN (1974). "Relationships among enzymes of the beta-ketoadipate pathway. IV. Muconolactone isomerase from Acinetobacter calcoaceticus and Pseudomonas putida." J Biol Chem 249(23);7410-9. PMID: 4215816
Stanier50: Stanier, R.Y., Sleeper, B.P., Tsuchida, M., MacDonald, D.L. (1950). "The bacterial oxidation of aromatic compounds; III. The enzymatic oxidation of catechol and protocatechuic acid to beta-ketoadipic acid." J Bacteriol 59(2): 137-151. PMID: 15421941
Lim02: Lim EK, Doucet CJ, Li Y, Elias L, Worrall D, Spencer SP, Ross J, Bowles DJ (2002). "The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates." J Biol Chem 277(1);586-92. PMID: 11641410
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