Caulobacter crescentus CB15 Pathway: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I

Pathway diagram: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Locations of Mapped Genes:

Schematic showing all replicons, marked with selected genes

Superclasses: Biosynthesis Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis Vitamins Biosynthesis Folate Biosynthesis 6-Hydroxymethyl-Dihydropterin Diphosphate Biosynthesis

Pathway Summary from MetaCyc:
6-hydroxymethyl-7,8-dihydropterin diphosphate (6-hydroxymethyl-dihydropterin diphosphate) is the pterin precursor for the biosynthesis of several important cofactors, including tetrahydropteroyl mono-L-glutamate, methanopterin and sarcinapterin. The compound is always synthesized from GTP, but the enzymes involve may differ among organisms.

This pathway, which is found in bacteria, fungi and plants, starts with GTP cyclohydrolase I, an enzyme that converts GTP into 7,8-dihydroneopterin 3'-triphosphate. The triphosphate motif is removed in a process that is still not completely understood, and the resulting 7,8-dihydroneopterin is converted to 6-hydroxymethyl-7,8-dihydropterin by dihydroneopterin aldolase (FolB).

In plants the pterin moiety is formed from GTP in the cytosol.

Superpathways: superpathway of tetrahydrofolate biosynthesis , superpathway of tetrahydrofolate biosynthesis and salvage

Pathway Evidence Glyph:

Pathway evidence glyph

Key to pathway glyph edge colors: ?

  An enzyme catalyzing this reaction is present in this organism
  No enzyme catalyzing this reaction has been identified in this organism
  The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway

Created 05-Mar-2009 by SRI International

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Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc13.