If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Locations of Mapped Genes:
|Superclasses:||Biosynthesis → Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis → Vitamins Biosynthesis → Folate Biosynthesis → 6-Hydroxymethyl-Dihydropterin Diphosphate Biosynthesis|
Pathway Summary from MetaCyc:
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (6-hydroxymethyl-dihydropterin diphosphate) is the pterin precursor for the biosynthesis of several important cofactors, including tetrahydropteroyl mono-L-glutamate, methanopterin and sarcinapterin. The compound is always synthesized from GTP, but the enzymes involve may differ among organisms.
This pathway, which is found in bacteria, fungi and plants, starts with GTP cyclohydrolase I, an enzyme that converts GTP into 7,8-dihydroneopterin 3'-triphosphate. The triphosphate motif is removed in a process that is still not completely understood, and the resulting 7,8-dihydroneopterin is converted to 6-hydroxymethyl-7,8-dihydropterin by dihydroneopterin aldolase (FolB).
In plants the pterin moiety is formed from GTP in the cytosol.
Pathway Evidence Glyph:
Key to pathway glyph edge colors:
An enzyme catalyzing this reaction is present in this organism
No enzyme catalyzing this reaction has been identified in this organism
The reaction and any enzyme that catalyzes it (if one has been identified) is unique to this pathway
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