Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Caulobacter crescentus CB15 Reaction: 2.7.1.69

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Group Translocation Phosphenolpyruvate (PEP)-Dependent Transport
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Conversion Type Simple Reactions Transport Reactions Group Translocation Phosphenolpyruvate (PEP)-Dependent Transport
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.7.1.69

Transporters and Genes:
PTS system, nitrogen regulatory IIA component : ptsN
PTS system, N-acetylglucosamine-specific IIABC component : nagE

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: protein-Nπ-phosphohistidine—sugar phosphotransferase

Enzyme Commission Synonyms: glucose permease, PTS permease, phosphotransferase, phosphohistidinoprotein-hexose, enzyme IIl4ac, gene glC proteins, gene bglC RNA formation factors, PEP-dependent phosphotransferase enzyme II, PEP-sugar phosphotransferase enzyme II, phosphoenolpyruvate-sugar phosphotransferase enzyme II, phosphohistidinoprotein-hexose phosphotransferase, phosphohistidinoprotein-hexose phosphoribosyltransferase, phosphoprotein factor-hexose phosophotransferase, protein, specific or class, gene bglC, ribonucleic acid formation factor, gene glC, sucrose phosphotransferase system II, protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase, protein-Npi-phosphohistidine:sugar Npi-phosphotransferase

Enzyme Commission Summary:
Enzyme II of the phosphotransferase system. Comprises a group of related enzymes. The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa). The protein is phosphorylated in a reaction catalysed by EC 2.7.3.9, phosphoenolpyruvate—protein phosphotransferase and this acts as the phosphate donor for the above reaction.

The enzyme translocates the sugar it phosphorylates into bacteria. Aldohexoses, and their glycosides and alditols, are phosphorylated on O-6, whereas fructose and sorbose are phosphorylated on O-1. Glycerone and disaccharides are also substrates.

Citations: [Kornberg76, Postma76]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.1.69 , ENZYME:EC:2.7.1.69 , IUBMB-ExplorEnz:EC:2.7.1.69


References

Kornberg76: Kornberg HL, Riordan C (1976). "Uptake of galactose into Escherichia coli by facilitated diffusion." J Gen Microbiol 94(1);75-89. PMID: 778334

Postma76: Postma, P.W., Roseman, S. (1976). "The bacterial phosphoenolpyruvate: sugar phosphotransferase system." Biochim Biophys Acta 457(3-4);213-57. PMID: 187249


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