Caulobacter crescentus CB15 Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:
glutamine cyclotransferase: CC2650

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutaminyl-peptide cyclotransferase

Enzyme Commission Synonyms: glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, glutaminyl-transfer ribonucleate cyclotransferase

Enzyme Commission Summary:
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.

Citations: [Busby87, Fischer87, Messer65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Busby87: Busby WH, Quackenbush GE, Humm J, Youngblood WW, Kizer JS (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes." J Biol Chem 262(18);8532-6. PMID: 3597387

Fischer87: Fischer WH, Spiess J (1987). "Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides." Proc Natl Acad Sci U S A 84(11);3628-32. PMID: 3473473

Messer65: Messer M, Ottesen M (1965). "Isolation and properties of glutamine cyclotransferase of dried papaya latex." C R Trav Lab Carlsberg 35(1);1-24. PMID: 5846578

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