Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Caulobacter crescentus CB15 Reaction: 2.3.2.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.3.2.5

Enzymes and Genes:
glutamine cyclotransferase : CC2650

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutaminyl-peptide cyclotransferase

Enzyme Commission Synonyms: glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, glutaminyl-transfer ribonucleate cyclotransferase

Enzyme Commission Summary:
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.

Citations: [Busby87, Fischer87, Messer65]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.3.2.5 , ENZYME:EC:2.3.2.5 , IUBMB-ExplorEnz:EC:2.3.2.5


References

Busby87: Busby WH, Quackenbush GE, Humm J, Youngblood WW, Kizer JS (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes." J Biol Chem 262(18);8532-6. PMID: 3597387

Fischer87: Fischer WH, Spiess J (1987). "Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides." Proc Natl Acad Sci U S A 84(11);3628-32. PMID: 3473473

Messer65: Messer M, Ottesen M (1965). "Isolation and properties of glutamine cyclotransferase of dried papaya latex." C R Trav Lab Carlsberg 35(1);1-24. PMID: 5846578


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