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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Caulobacter crescentus CB15 Reaction: 2.5.1.18

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.18

Enzymes and Genes:
glutathione S-transferase family protein : CC3639
glutathione S-transferase family protein : CC3088
glutathione S-transferase family protein : CC2901
glutathione S-transferase family protein : CC2843
glutathione S-transferase family protein : CC2647
glutathione S-transferase family protein : CC2594
glutathione S-transferase family protein : CC2484
glutathione S-transferase family protein : CC2434
glutathione S-transferase, putative : CC2311
glutathione S-transferase family protein : CC2309
glutathione S-transferase family protein : CC2088
glutathione S-transferase : CC2085
glutathione S-transferase family protein : CC1533
glutathione S-transferase family protein : CC1316
glutathione S-transferase family protein : CC1124
glutathione S-transferase family protein : CC0778
glutathione S-transferase family protein : CC0259
glutathione S-transferase family protein : CC0147
glutathione S-transferase : gst

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: glutathione transferase

Enzyme Commission Synonyms: glutathione S-transferase, glutathione S-alkyltransferase, glutathione S-aryltransferase, S-(hydroxyalkyl)glutathione lyase, glutathione S-aralkyltransferase, glutathione S-alkyl transferase, GST

Enzyme Commission Summary:
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.

Citations: [Habig74, Jakoby78, Keen78, Sheehan01, Jakoby85]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.5.1.18 , ENZYME:EC:2.5.1.18 , IUBMB-ExplorEnz:EC:2.5.1.18


References

Habig74: Habig WH, Pabst MJ, Jakoby WB (1974). "Glutathione S-transferases. The first enzymatic step in mercapturic acid formation." J Biol Chem 249(22);7130-9. PMID: 4436300

Jakoby78: Jakoby WB (1978). "The glutathione S-transferases: a group of multifunctional detoxification proteins." Adv Enzymol Relat Areas Mol Biol 46;383-414. PMID: 345769

Jakoby85: Jakoby WB (1985). "Glutathione transferases: an overview." Methods Enzymol 113;495-9. PMID: 4088070

Keen78: Keen JH, Jakoby WB (1978). "Glutathione transferases. Catalysis of nucleophilic reactions of glutathione." J Biol Chem 253(16);5654-7. PMID: 670218

Sheehan01: Sheehan D, Meade G, Foley VM, Dowd CA (2001). "Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily." Biochem J 360(Pt 1);1-16. PMID: 11695986


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