Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Caulobacter crescentus CB15 Reaction: 2.5.1.55

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.55

Enzymes and Genes:
2-dehydro-3-deoxyphosphooctonate aldolase : kdsA

In Pathway: CMP-KDO biosynthesis I , CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)

Supersedes EC number: 4.1.2.16

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-deoxy-8-phosphooctulonate synthase

Enzyme Commission Synonyms: 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphooctonate aldolase, 2-keto-3-deoxy-8-phosphooctonic synθse, 3-deoxy-D-manno-octulosonate-8-phosphate synthase, 3-deoxy-D-mannooctulosonate-8-phosphate synθse, 3-deoxyoctulosonic 8-phosphate synθse, KDOP synthase, phospho-2-keto-3-deoxyoctonate aldolase

Citations: [Krosky02, LEVIN59, Asojo01]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.5.1.55 , ENZYME:EC:2.5.1.55 , IUBMB-ExplorEnz:EC:2.5.1.55


References

Asojo01: Asojo O, Friedman J, Adir N, Belakhov V, Shoham Y, Baasov T (2001). "Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor." Biochemistry 40(21);6326-34. PMID: 11371194

Krosky02: Krosky DJ, Alm R, Berg M, Carmel G, Tummino PJ, Xu B, Yang W (2002). "Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme." Biochim Biophys Acta 1594(2);297-306. PMID: 11904225

LEVIN59: LEVIN DH, RACKER E (1959). "Condensation of arabinose 5-phosphate and phosphorylenol pyruvate by 2-keto-3-deoxy-8-phosphooctonic acid synthetase." J Biol Chem 234;2532-9. PMID: 14416200


Report Errors or Provide Feedback
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14B.