Escherichia coli K-12 substr. MG1655 Compound Class: a prosthetic group

Superclasses: a cofactor

A prosthetic group is a term for a compound or ion that is essential for the activity of an enzyme, and is tightly bound to the enzyme.

Child Classes: a biopterin (0), a coenzyme F420 (0), a folate (13), a metal-sulfur cluster (0), a methanofuran (0), a Mo-molybdopterin cofactor (5)

coenzyme A,


Allen14: Allen KD, White RH (2014). "Identification of structurally diverse methanofuran coenzymes in methanococcales that are both N-formylated and N-acetylated." Biochemistry 53(39);6199-210. PMID: 25203397

Bobik87: Bobik TA, Donnelly MI, Rinehart KL, Wolfe RS (1987). "Structure of a methanofuran derivative found in cell extracts of Methanosarcina barkeri." Arch Biochem Biophys 254(2);430-6. PMID: 2883935

Cheeseman72: Cheeseman P, Toms-Wood A, Wolfe RS (1972). "Isolation and properties of a fluorescent compound, factor 420 , from Methanobacterium strain M.o.H." J Bacteriol 112(1);527-31. PMID: 5079072

Chistoserdova98: Chistoserdova L, Vorholt JA, Thauer RK, Lidstrom ME (1998). "C1 transfer enzymes and coenzymes linking methylotrophic bacteria and methanogenic Archaea." Science 281(5373);99-102. PMID: 9651254

Choi01: Choi KP, Bair TB, Bae YM, Daniels L (2001). "Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG." J Bacteriol 183(24);7058-66. PMID: 11717263

Eirich78: Eirich LD, Vogels GD, Wolfe RS (1978). "Proposed structure for coenzyme F420 from Methanobacterium." Biochemistry 17(22);4583-93. PMID: 728375

Eisenreich92: Eisenreich W, Bacher A (1992). "Biosynthesis of methanofuran in Methanobacterium thermoautotrophicum." J Biol Chem 267(25);17574-80. PMID: 1517208

Graham02: Graham DE, White RH (2002). "Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics." Nat Prod Rep 19(2);133-47. PMID: 12013276

Graupner03: Graupner M, White RH (2003). "Methanococcus jannaschii coenzyme F420 analogs contain a terminal alpha-linked glutamate." J Bacteriol 185(15);4662-5. PMID: 12867481

Hanson02: Hanson AD, Gregory JF (2002). "Synthesis and turnover of folates in plants." Curr Opin Plant Biol 5(3);244-9. PMID: 11960743

Jabrin03: Jabrin S, Ravanel S, Gambonnet B, Douce R, Rebeille F (2003). "One-carbon metabolism in plants. Regulation of tetrahydrofolate synthesis during germination and seedling development." Plant Physiol 131(3);1431-9. PMID: 12644692

Li03: Li H, Xu H, Graham DE, White RH (2003). "Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses." Proc Natl Acad Sci U S A 100(17);9785-90. PMID: 12909715

Lucock00: Lucock M (2000). "Folic acid: nutritional biochemistry, molecular biology, and role in disease processes." Mol Genet Metab 71(1-2);121-38. PMID: 11001804

Miller14: Miller D, Wang Y, Xu H, Harich K, White RH (2014). "Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran." Biochemistry 53(28);4635-47. PMID: 24977328

Pomper01: Pomper BK, Vorholt JA (2001). "Characterization of the formyltransferase from Methylobacterium extorquens AM1." Eur J Biochem 268(17);4769-75. PMID: 11532013

White88: White RH (1988). "Structural diversity among methanofurans from different methanogenic bacteria." J Bacteriol 170(10);4594-7. PMID: 3170480

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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