Escherichia coli K-12 substr. MG1655 Compound Class: a 2'-deoxynucleoside

Synonyms: a deoxynucleoside

Superclasses: a nucleic acid componenta nucleoside

Nucleosides are glycosylamines consisting of a nucleobase bound to a ribose or 2'-deoxyribose sugar via a β-glycosidic linkage. The nucleosides are called ribonucleosides when the sugar is ribose, and deoxyribonucleosides when it is 2'-deoxyribose.

Common ribonucleosides include cytidine, uridine, adenosine, guanosine and inosine. Examples of deoxyribonucleosides include thymidine and 2'-deoxyadenosine.

When nucleosides are phosphorylated on the sugar's primary alcohol group, the resulting phosphonucleosides are called nucleotides.

a 2'-deoxynucleoside compound structure

Child Classes: a modified 2'-deoxyribonucleoside (1), a purine 2'-deoxyribonucleoside (3), a pyrimidine 2'-deoxyribonucleoside (3), a tRNA ribothymidine (0)

SMILES: C1(C([a nucleobase])OC(CO)C(O)1)

Unification Links: KEGG:C02269

Reactions known to produce the compound:

Not in pathways:
a 2'-deoxyribonucleoside 5'-monophosphate + H2O → a 2'-deoxynucleoside + phosphate
a 2'-deoxyribonucleoside 3'-monophosphate[periplasm] + H2O[periplasm]a 2'-deoxynucleoside[periplasm] + phosphate[periplasm]

Not in pathways:
a nucleoside 5'-monophosphate[periplasm] + H2O[periplasm]a nucleoside[periplasm] + phosphate[periplasm]

In Transport reactions:
a nucleoside[extracellular space]a nucleoside[periplasm],
a nucleoside[periplasm] + H+[periplasm]a nucleoside[cytosol] + H+[cytosol]

Enzymes inhibited by a 2'-deoxynucleoside, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: acid phosphatase / phosphotransferase [Thaller97]


Thaller97: Thaller MC, Schippa S, Bonci A, Cresti S, Rossolini GM (1997). "Identification of the gene (aphA) encoding the class B acid phosphatase/phosphotransferase of Escherichia coli MG1655 and characterization of its product." FEMS Microbiol Lett 1997;146(2);191-8. PMID: 9011040

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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