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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0004518 - nuclease activity

Definition: Catalysis of the hydrolysis of ester linkages within nucleic acids.

Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.

Parent Classes:
GO:0016788 - hydrolase activity, acting on ester bonds

Child Classes:
GO:0004519 - endonuclease activity (62),
GO:0004527 - exonuclease activity (32),
GO:0004536 - deoxyribonuclease activity (38),
GO:0004540 - ribonuclease activity (34),
GO:0008946 - oligonucleotidase activity (1)

Term Members:
RNA/ssDNA exonuclease 5' → 3' specific (yciV),
Rac prophage; DNA endonuclease toxin of the RalRA toxin-antitoxin system, restriction alleviation and modification enhancement,
antitoxin of the GhoTS toxin-antitoxin system (ghoS),
flap endonuclease (ygdG),
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system,
toxin of the YafQ-DinJ toxin-antitoxin system,
multifunctional nuclease Cas1,
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system,
toxin of the HicA-HicB toxin-antitoxin system,
conserved protein with endonuclease activity (smrA),
endonuclease V (nfi),
YhaV toxic ribonuclease,
translation-dependent mRNA interferase, toxin of the HigB-HigA toxin-antitoxin system,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system,
ChpB toxin of the ChpB-ChpS toxin-antitoxin system,
ribonuclease II (rnb),
ssDNA/RNA exonuclease, 3' → 5' specific (tatD),
DNA-specific endonuclease I (endA),
methylated adenine and cytosine restriction protein (mrr),
RNase R (rnr),
RNase I, cleaves phosphodiester bond between any two nucleotides,
exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific (recE),
ATP-dependent dsDNA exonuclease (sbcC),
RNAse HII, degrades RNA of DNA-RNA hybrids (rnhB),
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB,
endodeoxyribonuclease RUS (Holliday junction resolvase) (rusA),
exonuclease X (exoX),
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity,
ribonuclease G (RNAse G) monomer (rng),
endoribonuclease involved in maturation of 16S rRNA and ribosome quality control (ybeY),
Holliday junction nuclease; resolution of structures; repair (ruvC),
RNase P protein component; processes tRNA, 4.5S RNA (rnpA),
RNase HI, degrades RNA of DNA-RNA hybrids, participates in DNA replication (rnhA),
RNase III (rnc),
30S ribosomal subunit protein S16 (rpsP),
oligoribonuclease monomer (orn),
endonuclease IV (nfo),
DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway (vsr),
RNase D (rnd),
exonuclease III (xthA),
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB),
DNA polymerase III, ε subunit (dnaQ),
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA),
DLP12 prophage; predicted exonuclease (ybcC),
conserved protein (yraN),
crRNA endonuclease (casE),
Cas2 protein,
Cas3 nuclease/helicase,
toxin of the YoeB-YefM toxin-antitoxin pair,
endonuclease of nucleotide excision repair (cho),
predicted DNase (yjjV),
toxin-like protein of the SOS response (symE),
restriction of DNA at 5-methylcytosine residues (mcrA),
RNase E (rne),
MrcB subunit of 5-methylcytosine restriction system (mcrB),
ATP-dependent dsDNA exonuclease (sbcD),
predicted metallodependent hydrolase (ycfH),
predicted transcription antitermination factor (yqgF),
exonuclease VII, small subunit (xseB),
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC),
DNA repair; excision nuclease subunit B (uvrB),
excision nuclease subunit A (uvrA),
exonuclease VII, large subunit (xseA)

Unification Links: GO:0004518

Relationship Links: ENZYME:RELATED-TO:3.1.-.-

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc13.