Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0004518 - nuclease activity

Definition: Catalysis of the hydrolysis of ester linkages within nucleic acids.

Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.

Parent Classes:
GO:0016788 - hydrolase activity, acting on ester bonds

Child Classes:
GO:0004519 - endonuclease activity (60) ,
GO:0004527 - exonuclease activity (30) ,
GO:0004536 - deoxyribonuclease activity (35) ,
GO:0004540 - ribonuclease activity (31) ,
GO:0008946 - oligonucleotidase activity (1)

Term Members:
flap endonuclease (ygdG) ,
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system ,
toxin of the YafQ-DinJ toxin-antitoxin system ,
multifunctional nuclease (cas1) ,
mRNA interferase, toxin of the MqsR-MqsA toxin-antitoxin system ,
toxin of the HicA-HicB toxin-antitoxin system ,
conserved protein with endonuclease activity (smrA) ,
endonuclease V (deoxyinosine 3'-endonuclease) (nfi) ,
YhaV toxic ribonuclease ,
translation-dependent mRNA interferase, toxin of the HigB-HigA toxin-antitoxin system ,
CP4-57 prophage; RNase LS, toxin of the RnlAB toxin-antitoxin system ,
ChpB toxin of the ChpB-ChpS toxin-antitoxin system ,
ribonuclease II (rnb) ,
Rnt ,
ssDNA/RNA exonuclease, 3' → 5' specific (tatD) ,
DNA-specific endonuclease I (endA) ,
methylated adenine and cytosine restriction protein (mrr) ,
RNase R (rnr) ,
RNase I, cleaves phosphodiester bond between any two nucleotides ,
exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific (recE) ,
ATP-dependent dsDNA exonuclease (sbcC) ,
RNAse HII, degrades RNA of DNA-RNA hybrids (rnhB) ,
Qin prophage; toxin of the RelE-RelB toxin-antitoxin system and cofactor to enhance the repressor activity of RelB ,
endodeoxyribonuclease RUS (Holliday junction resolvase) (rusA) ,
exonuclease X (exoX) ,
MazF toxin of the MazF-MazE toxin-antitoxin system that exhibits ribonuclease activity ,
ribonuclease G (RNAse G) monomer (rng) ,
endoribonuclease involved in maturation of 16S rRNA and ribosome quality control (ybeY) ,
Holliday junction nuclease; resolution of structures; repair (ruvC) ,
RNase P protein component; processes tRNA, 4.5S RNA (rnpA) ,
RNase HI, degrades RNA of DNA-RNA hybrids, participates in DNA replication (rnhA) ,
RNase III (rnc) ,
30S ribosomal subunit protein S16 (rpsP) ,
oligoribonuclease monomer (orn) ,
endonuclease IV (nfo) ,
DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway (vsr) ,
RNase D (rnd) ,
exonuclease III (xthA) ,
RecB ,
RecC ,
MutH ,
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB) ,
RecD ,
DNA polymerase III, ε subunit (dnaQ) ,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA) ,
DLP12 prophage; predicted exonuclease (ybcC) ,
conserved protein (yraN) ,
crRNA endonuclease (casE) ,
predicted endoribonuclease (cas2) ,
protein involved in CRISPR R-loop formation and dissociation (cas3) ,
toxin of the YoeB-YefM toxin-antitoxin pair ,
endonuclease of nucleotide excision repair (cho) ,
predicted DNase (yjjV) ,
toxin-like protein of the SOS response (symE) ,
restriction of DNA at 5-methylcytosine residues (mcrA) ,
RecJ ,
RNase E (rne) ,
MrcB subunit of 5-methylcytosine restriction system (mcrB) ,
ATP-dependent dsDNA exonuclease (sbcD) ,
predicted metallodependent hydrolase (ycfH) ,
Rbn ,
predicted transcription antitermination factor (yqgF) ,
exonuclease VII, small subunit (xseB) ,
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC) ,
DNA repair; excision nuclease subunit B (uvrB) ,
excision nuclease subunit A (uvrA) ,
exonuclease VII, large subunit (xseA)

Unification Links: GO:0004518

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Apr 25, 2015, BIOCYC14B.