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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0004812 - aminoacyl-tRNA ligase activity

Synonyms: GO:0017100, aminoacyl-tRNA synthetase activity

Definition: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.

Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.

Parent Classes:
GO:0016876 - ligase activity, forming aminoacyl-tRNA and related compounds

Child Classes:
GO:0004813 - alanine-tRNA ligase activity (1),
GO:0004814 - arginine-tRNA ligase activity (2),
GO:0004815 - aspartate-tRNA ligase activity (1),
GO:0004816 - asparagine-tRNA ligase activity (1),
GO:0004817 - cysteine-tRNA ligase activity (1),
GO:0004818 - glutamate-tRNA ligase activity (1),
GO:0004819 - glutamine-tRNA ligase activity (1),
GO:0004820 - glycine-tRNA ligase activity (2),
GO:0004821 - histidine-tRNA ligase activity (1),
GO:0004822 - isoleucine-tRNA ligase activity (1),
GO:0004823 - leucine-tRNA ligase activity (1),
GO:0004824 - lysine-tRNA ligase activity (3),
GO:0004825 - methionine-tRNA ligase activity (1),
GO:0004826 - phenylalanine-tRNA ligase activity (3),
GO:0004827 - proline-tRNA ligase activity (1),
GO:0004828 - serine-tRNA ligase activity (1),
GO:0004829 - threonine-tRNA ligase activity (1),
GO:0004830 - tryptophan-tRNA ligase activity (1),
GO:0004831 - tyrosine-tRNA ligase activity (1),
GO:0004832 - valine-tRNA ligase activity (1)

Term Members:
histidyl-tRNA synthetase (hisS),
aspartyl-tRNA synthetase (aspS),
cysteinyl-tRNA synthetase (cysS),
prolyl-tRNA synthetase (proS),
lysyl-tRNA synthetase (lysU),
threonyl-tRNA synthetase (thrS),
seryl-tRNA synthetase (serS),
leucyl-tRNA synthetase (leuS),
glutamyl-tRNA synthetase (gltX),
glutaminyl-tRNA synthetase (glnS),
alanyl-tRNA synthetase (alaS),
EF-P-lysine lysyltransferase (epmA),
lysyl tRNA synthetase (LysRSs), constitutive (lysS),
glutamyl-Q tRNAAsp synthetase (gluQ),
arginyl-tRNA synthetase (argS),
tyrosyl-tRNA synthetase (tyrS),
asparaginyl-tRNA synthetase (asnS),
phenylalanyl-tRNA synthetase α-chain (pheS),
phenylalanyl-tRNA synthetase β-chain (pheT),
valyl-tRNA synthetase (valS),
glycyl-tRNA synthetase, β subunit (glyS),
glycyl-tRNA synthetase, α subunit (glyQ),
methionyl-tRNA synthetase (metG),
isoleucyl-tRNA synthetase (ileS),
tryptophanyl-tRNA synthetase (trpS)

Unification Links: GO:0004812

Relationship Links: ENZYME:RELATED-TO:6.1.1.-

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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