Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006099 - tricarboxylic acid cycle

Synonyms: citric acid cycle, Krebs cycle, TCA cycle

Definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Parent Classes:
GO:0006101 - citrate metabolic process,
GO:0044238 - primary metabolic process

Part Of:
GO:0009060 - aerobic respiration

Term Members:
predicted acyl-CoA synthetase with NAD(P)-binding Rossmann-fold domain (fdrA),
predicted acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain (yahF),
2-methylcitrate dehydratase (prpD),
2-methylcitrate synthase (prpC),
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA),
succinate:quinone oxidoreductase subcomplex,
malate synthase G (glcB),
fumarate reductase iron-sulfur protein (frdB),
isocitrate lyase monomer (aceA),
malate synthase A (aceB),
succinyl-CoA synthetase, β subunit,
succinyl-CoA synthetase, α subunit (sucD),
succinate:quinone oxidoreductase, FAD binding protein (sdhA),
malate dehydrogenase (mdh),
fumarase C monomer (fumC),
fumarase B monomer (fumB),
fumarase A monomer,
malate:quinone oxidoreductase (mqo),
citrate synthase monomer (gltA),
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB),
aconitate hydratase 1 (acnA),
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (sdhB),
succinate:quinone oxidoreductase, membrane protein SdhC,
succinate:quinone oxidoreductase, membrane protein SdhD

Unification Links: GO:0006099

Relationship Links: MetaCyc:RELATED-TO:P42-PWY, MetaCyc:RELATED-TO:P105-PWY, MetaCyc:RELATED-TO:TCA, Reactome:RELATED-TO:REACT_1785, Reactome:RELATED-TO:REACT_33923, Reactome:RELATED-TO:REACT_54425, Reactome:RELATED-TO:REACT_81042, Reactome:RELATED-TO:REACT_82509, Reactome:RELATED-TO:REACT_82906, Reactome:RELATED-TO:REACT_83116, Reactome:RELATED-TO:REACT_83923, Reactome:RELATED-TO:REACT_84181, Reactome:RELATED-TO:REACT_85849, Reactome:RELATED-TO:REACT_89038, Reactome:RELATED-TO:REACT_89851, Reactome:RELATED-TO:REACT_90664, Reactome:RELATED-TO:REACT_94857, Reactome:RELATED-TO:REACT_98104, Reactome:RELATED-TO:REACT_98794, Reactome:RELATED-TO:REACT_101296, Reactome:RELATED-TO:REACT_101797, Reactome:RELATED-TO:REACT_105180, Reactome:RELATED-TO:REACT_110534, Reactome:RELATED-TO:REACT_110779, Reactome:RELATED-TO:REACT_115536, Wikipedia:RELATED-TO:Tricarboxylic_acid_cycle

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.