Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006099 - tricarboxylic acid cycle

Synonyms: citric acid cycle, Krebs cycle, TCA cycle

Definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Parent Classes:
GO:0006101 - citrate metabolic process ,
GO:0044238 - primary metabolic process

Part Of:
GO:0009060 - aerobic respiration

Term Members:
2-methylcitrate dehydratase (prpD) ,
2-methylcitrate synthase (prpC) ,
subunit of E1(0) component of 2-oxoglutarate dehydrogenase (sucA) ,
AspA ,
Ppc ,
succinate:quinone oxidoreductase subcomplex ,
malate synthase G (glcB) ,
AceK ,
SucB ,
fumarate reductase iron-sulfur protein (frdB) ,
isocitrate lyase monomer (aceA) ,
malate synthase A (aceB) ,
succinyl-CoA synthetase, β subunit ,
succinyl-CoA synthetase, α subunit (sucD) ,
succinate:quinone oxidoreductase, FAD binding protein (sdhA) ,
malate dehydrogenase (mdh) ,
Icd ,
fumarase C monomer (fumC) ,
fumarase B monomer (fumB) ,
fumarase A monomer ,
malate:quinone oxidoreductase (mqo) ,
citrate synthase monomer (gltA) ,
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB) ,
aconitate hydratase 1 (acnA) ,
succinate:quinone oxidoreductase, iron-sulfur cluster binding protein (sdhB) ,
succinate:quinone oxidoreductase, membrane protein SdhC ,
succinate:quinone oxidoreductase, membrane protein SdhD

Unification Links: GO:0006099

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Thu Oct 8, 2015, biocyc13.