Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006265 - DNA topological change

Definition: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.

Parent Classes:
GO:0006259 - DNA metabolic process ,
GO:0071103 - DNA conformation change

Term Members:
predicted DNA topoisomerase (yrdD) ,
DNA topoisomerase III (topB) ,
DNA gyrase, subunit A ,
DNA topoisomerase I (topA) ,
topoisomerase IV subunit B (parE) ,
topoisomerase IV subunit A (parC) ,
DNA gyrase, subunit B (gyrB)

Unification Links: GO:0006265

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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