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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006289 - nucleotide-excision repair

Synonyms: GO:0045001, NER, pyrimidine-dimer repair, DNA damage excision

Definition: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.

Parent Classes:
GO:0006281 - DNA repair

Child Classes:
GO:0006283 - transcription-coupled nucleotide-excision repair

GO:0000715 - nucleotide-excision repair, DNA damage recognition (1)

Term Members:
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC),
endonuclease VIII (nei),
DNA repair; excision nuclease subunit B (uvrB),
excision nuclease subunit A (uvrA),
formamidopyrimidine DNA glycosylase (mutM)

Unification Links: GO:0006289

Relationship Links: Reactome:RELATED-TO:REACT_1826, Reactome:RELATED-TO:REACT_30685, Reactome:RELATED-TO:REACT_31605, Reactome:RELATED-TO:REACT_71449, Reactome:RELATED-TO:REACT_77033, Reactome:RELATED-TO:REACT_79939, Reactome:RELATED-TO:REACT_81923, Reactome:RELATED-TO:REACT_84438, Reactome:RELATED-TO:REACT_85405, Reactome:RELATED-TO:REACT_88933, Reactome:RELATED-TO:REACT_91101, Reactome:RELATED-TO:REACT_96106, Reactome:RELATED-TO:REACT_98428, Reactome:RELATED-TO:REACT_98432, Reactome:RELATED-TO:REACT_103880, Reactome:RELATED-TO:REACT_103962, Reactome:RELATED-TO:REACT_106982, Reactome:RELATED-TO:REACT_109142, Reactome:RELATED-TO:REACT_110113

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc11.