Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006400 - tRNA modification

Synonyms: GO:0016549

Definition: The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.

Parent Classes:
GO:0008033 - tRNA processing,
GO:0009451 - RNA modification

Child Classes:
GO:0002097 - tRNA wobble base modification (17),
GO:0002943 - tRNA dihydrouridine synthesis (3),
GO:0002949 - tRNA threonylcarbamoyladenosine modification (4),
GO:0019988 - charged-tRNA amino acid modification (1),
GO:0030488 - tRNA methylation (17),
GO:0031119 - tRNA pseudouridine synthesis (6),
GO:0034227 - tRNA thio-modification (7),
GO:0035600 - tRNA methylthiolation (2),
GO:0051391 - tRNA acetylation (1),
GO:0061504 - cyclic threonylcarbamoyladenosine biosynthetic process (1),
GO:0070329 - tRNA seleno-modification (2)

Term Members:
tRNA-guanine transglycosylase monomer (tgt),
alanyl-tRNA synthetase (alaS),
tRNA pseudouridine 55 synthase (truB),
tRNA U34 carboxymethyltransferase (cmoB),
glutamyl-Q tRNAAsp synthetase (gluQ),
tRNA-specific 2-thiouridylase (mnmA),
GTPase, involved in modification of U34 in tRNA (mnmE),
tRNA m1G37 methyltransferase (trmD),
carboxy-S-adenosyl-L-methionine synthase (cmoA),
isopentenyl-adenosine A37 tRNA methylthiolase (miaB),
tRNA m7G46 methyltransferase (trmI),
tRNAIle-lysidine synthetase (tilS),
tRNA(i6A37) synthase (miaA),
tRNA C32 thiolase (ttcA)

Unification Links: GO:0006400

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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