Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006508 - proteolysis

Synonyms: peptidolysis

Definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Parent Classes:
GO:0019538 - protein metabolic process

Child Classes:
GO:0016485 - protein processing (13),
GO:0051603 - proteolysis involved in cellular protein catabolic process (8),
GO:0070646 - protein modification by small protein removal (1),
GO:0097264 - self proteolysis (8)

Term Members:
specificity factor for ClpA-ClpP chaperone-protease complex (clpS),
prepilin peptidase (pppA),
penicillin binding protein 4B (yfeW),
Mlc titration factor (mtfA),
N6-L-threonylcarbamoyladenine synthase, TsaB subunit,
L,D-transpeptidase LdtE,
L,D-transpeptidase YcfS (ldtC),
L,D-transpeptidase ErfK (ldtA),
predicted ATP-dependent protease (yifB),
L,D-transpeptidase LdtD,
Lit, cell death peptidase; phage exclusion; e14 prophage,
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA),
L,D-transpeptidase YbiS (ldtB),
endoribonuclease involved in maturation of 16S rRNA and ribosome quality control (ybeY),
ATPase component of the HslVU protease (hslU),
N6-L-threonylcarbamoyladenine synthase, TsaD subunit,
predicted protein (yedK),
γ-glutamyltranspeptidase (ggt),
chaperone/protease involved in the maintenance of OM integrity (bepA),
predicted protease (yhbV),
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB),
penicillin-binding protein 7 (pbpG),
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE),
murein tripeptide amidase A (mpaA),
L,D-carboxypeptidase A (ldcA),
DD-endopeptidase / DD-carboxypeptidase (ampH),
intramembrane serine protease GlpG,
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (tldD),
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (pmbA),
predicted lipoprotein and C40 family peptidase (yafL),
broad-specificity exoaminopeptidase (ypdE),
Rac prophage; predicted defective peptidase (rzpR),
murein DD-endopeptidase MepH,
DLP12 prophage; predicted murein endopeptidase (rzpD),
KpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain (sgcX),
predicted maturation peptidase for hydrogenase 2 (hybD),
predicted lipoprotein (yaeF),
frv operon protein (frvX),
leader peptidase, integral membrane protein (gspO),
NlpC-putative lipoprotein hydrolase,
protein involved in processing of HyaA and HyaB proteins (hyaD),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
murein DD-endopeptidase / murein LD-carboxypeptidase (mepS),
hydrogenase 3 maturation protease (hycI),
deubiquitinase (elaD),
aminopeptidase (ypdF),
predicted peptidase (yegQ),
predicted peptidase (ydgD),
predicted peptidase (ydcP),
predicted peptidase (ygeY),
predicted peptidase (collagenase-like) (yhbU),
predicted peptidase with chaperone function (ycaL),
predicted zinc-dependent peptidase (yhjJ),
DD-carboxypeptidase, penicillin-binding protein 6b (dacD),
putative zinc peptidase (pqqL),
outer membrane metallopeptidase (loiP),
heat shock protein, integral membrane protein (htpX),
alkaline phosphatase isozyme conversion protein (iap),
predicted inner membrane peptidase (sohB),
murein DD-endopeptidase MepM,
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA),
methionine aminopeptidase (map),
outer membrane protease VII (outer membrane protein 3b) (ompT),
penicillin-binding protein 6 (dacC),
prolipoprotein signal peptidase II (lspA),
leader peptidase (signal peptidase I) (lepB),
protease IV (sppA),
serine endoprotease, periplasmic monomer (degQ),
D-Ala-D-Ala dipeptidase (ddpX),
putative ATP-dependent protease (ycbZ),
RseP zinc protease, signal peptide peptidase,
aminopeptidase B (pepB),
peptidase E, a dipeptidase where amino-terminal residue is aspartate (pepE),
peptidase component of the HslVU protease,
Deg S monomer (degS),
peptidase T,
ATP-dependent zinc metalloprotease FtsH,
oligopeptidase A (prlC),
oligopeptidase B (ptrB),
protease III (ptrA),
tail-specific protease (prc),
Xaa-Pro dipeptidase (pepQ),
aminopeptidase N (pepN),
peptidase D (pepD),
aminopeptidase A/I (pepA),
dipeptidyl carboxypeptidase II (dcp),

Unification Links: GO:0006508

Relationship Links: Reactome:RELATED-TO:REACT_733, Reactome:RELATED-TO:REACT_84556, Reactome:RELATED-TO:REACT_92566, Reactome:RELATED-TO:REACT_95969, Reactome:RELATED-TO:REACT_98959, Reactome:RELATED-TO:REACT_105459, Reactome:RELATED-TO:REACT_106013, Reactome:RELATED-TO:REACT_106377, Reactome:RELATED-TO:REACT_107219, Reactome:RELATED-TO:REACT_110326, Wikipedia:RELATED-TO:Proteolysis

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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