Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006508 - proteolysis

Synonyms: peptidolysis

Definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Parent Classes:
GO:0019538 - protein metabolic process

Child Classes:
GO:0016485 - protein processing (11) ,
GO:0051603 - proteolysis involved in cellular protein catabolic process (9) ,
GO:0070646 - protein modification by small protein removal (1) ,
GO:0097264 - self proteolysis (8)

Term Members:
specificity factor for ClpA-ClpP chaperone-protease complex (clpS) ,
prepilin peptidase (pppA) ,
penicillin binding protein 4B (yfeW) ,
Mlc titration factor (mtfA) ,
protein involved in threonylcarbamoyladenosine biosynthesis (tsaB) ,
L,D-transpeptidase LdtE ,
L,D-transpeptidase YcfS (ldtC) ,
L,D-transpeptidase ErfK (ldtA) ,
predicted ATP-dependent protease (yifB) ,
L,D-transpeptidase LdtD ,
Lit, cell death peptidase; phage exclusion; e14 prophage ,
cell shape; peptidoglycan synthetase; penicillin-binding protein 2 (mrdA) ,
L,D-transpeptidase YbiS (ldtB) ,
endoribonuclease involved in maturation of 16S rRNA and ribosome quality control (ybeY) ,
ATPase component of the HslVU protease (hslU) ,
ClpX ,
protein involved in threonylcarbamoyladenosine biosynthesis (tsaD) ,
MrcB ,
MrcA ,
predicted protein (yedK) ,
γ-glutamyltranspeptidase (ggt) ,
ClpP ,
chaperone/protease involved in the maintenance of OM integrity (bepA) ,
predicted protease (yhbV) ,
meso-diaminopimelic acid-D-alanyl endopeptidase / D-alanyl-D-alanine carboxypeptidase (dacB) ,
ArgE ,
penicillin-binding protein 7 (pbpG) ,
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE) ,
murein tripeptide amidase A (mpaA) ,
TolB ,
LexA ,
L,D-carboxypeptidase A (ldcA) ,
IadA ,
DD-endopeptidase / DD-carboxypeptidase (ampH) ,
intramembrane serine protease GlpG ,
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (tldD) ,
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (pmbA) ,
predicted lipoprotein and C40 family peptidase (yafL) ,
broad-specificity exoaminopeptidase (ypdE) ,
Rac prophage; predicted defective peptidase (rzpR) ,
murein DD-endopeptidase MepH ,
DLP12 prophage; predicted murein endopeptidase (rzpD) ,
KpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain (sgcX) ,
IaaA ,
predicted maturation peptidase for hydrogenase 2 (hybD) ,
predicted lipoprotein (yaeF) ,
frv operon protein (frvX) ,
leader peptidase, integral membrane protein (gspO) ,
NlpC-putative lipoprotein hydrolase ,
protein involved in processing of HyaA and HyaB proteins (hyaD) ,
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC ,
murein LD-carboxypeptidase / murein DD-endopeptidase (mepS) ,
hydrogenase 3 maturation protease (hycI) ,
TesA ,
deubiquitinase (elaD) ,
aminopeptidase (ypdF) ,
predicted peptidase (yegQ) ,
predicted peptidase (ydgD) ,
predicted peptidase (ydcP) ,
predicted peptidase (ygeY) ,
predicted peptidase (collagenase-like) (yhbU) ,
predicted peptidase with chaperone function (ycaL) ,
predicted zinc-dependent peptidase (yhjJ) ,
DD-carboxypeptidase, penicillin-binding protein 6b (dacD) ,
putative zinc peptidase (pqqL) ,
outer membrane metallopeptidase (loiP) ,
heat shock protein, integral membrane protein (htpX) ,
alkaline phosphatase isozyme conversion protein (iap) ,
MepA ,
predicted inner membrane peptidase (sohB) ,
murein DD-endopeptidase MepM ,
D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 (dacA) ,
methionine aminopeptidase (map) ,
outer membrane protease VII (outer membrane protein 3b) (ompT) ,
penicillin-binding protein 6 (dacC) ,
prolipoprotein signal peptidase II (lspA) ,
leader peptidase (signal peptidase I) (lepB) ,
protease IV (sppA) ,
serine endoprotease, periplasmic (degQ) ,
D-Ala-D-Ala dipeptidase (ddpX) ,
putative ATP-dependent protease (ycbZ) ,
RseP zinc protease, signal peptide peptidase ,
aminopeptidase B (pepB) ,
peptidase E, a dipeptidase where amino-terminal residue is aspartate (pepE) ,
peptidase component of the HslVU protease ,
DegS serine endoprotease ,
peptidase T ,
ATP-dependent zinc metalloprotease FtsH ,
oligopeptidase A (prlC) ,
oligopeptidase B (ptrB) ,
protease III (ptrA) ,
tail-specific protease (prc) ,
Xaa-Pro dipeptidase (pepQ) ,
PepP ,
aminopeptidase N (pepN) ,
peptidase D (pepD) ,
aminopeptidase A/I (pepA) ,
Lon ,
DegP ,
dipeptidyl carboxypeptidase II (dcp) ,

Unification Links: GO:0006508

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, biocyc13.