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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006974 - cellular response to DNA damage stimulus

Synonyms: GO:0034984, cellular DNA damage response, DNA damage response, response to genotoxic stress

Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

Parent Classes:
GO:0033554 - cellular response to stress

Child Classes:
GO:0006281 - DNA repair (82),
GO:0031297 - replication fork processing (3)

Term Members:
conserved metal-binding protein (ybgI),
DNA base-flipping protein (atl),
RNA ligase (rtcB),
conserved protein (yggE),
endonuclease VIII (nei),
DNA recombination protein (radA),
DNA polymerase II (polB),
adenine glycosylase; G.C --> T.A transversions (mutY),
endodeoxyribonuclease RUS (Holliday junction resolvase) (rusA),
exonuclease X (exoX),
stationary phase mismatch/uracil DNA glycosylase (mug),
Holliday junction nuclease; resolution of structures; repair (ruvC),
branch migration of Holliday structures; repair helicase (ruvB),
branch migration of Holliday structures; repair (ruvA),
recombination and repair (recR),
ssDNA and dsDNA binding, ATP binding (recF),
endonuclease IV (nfo),
excision nuclease subunit A (uvrA),
DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway (vsr),
AlkB repair system for alkylated DNA and RNA,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA),
transcription-repair coupling factor (mfd),
SSB monomer,
30S ribosome binding factor (rbfA),
predicted protein (yaaY),
RNA chaperone, involved in posttranscriptional control of ProP levels (proQ),
nucleotide binding protein (yajQ),
ATP-dependent dsDNA exonuclease (sbcC),
conserved protein, involved in DNA damage response (yfgI),
ATP-dependent DNA helicase (recQ),
homocysteine S-methyltransferase (mmuM),
predicted glucosyltransferase (yaiP),
L-glyceraldehyde 3-phosphate reductase (yghZ),
putative lipoprotein (yghG),
isopentenyl diphosphate isomerase (idi),
NADPH-dependent FMN reductase (ssuE),
hydrogenase 4, component C (hyfC),
predicted periplasmic pilin chaperone (yqiH),
conserved protein (ydhQ),
aldehyde dehydrogenase: molybdenum cofactor-binding subunit (paoC),
hydrogenase 4, component F (hyfF),
tartronate semialdehyde reductase 2 (glxR),
predicted inner membrane protein (yqiJ),
predicted deoxygluconate dehydrogenase (ygcW),
conserved protein (yphB),
predicted sensory kinase in two-component regulatory system with YedW (yedV),
predicted c-di-GMP phosphodiesterase (pdeD),
conserved protein (ydiQ),
predicted anaerobic sulfatase maturation enzyme (ydeM),
putrescine:H+ symporter PuuP,
DNA-binding transcriptional regulator (yciT),
dihydroxyacetone kinase subunit K (dhaK),
predicted protein (ycfL),
protein involved in maturation of YcdX (ycdY),
predicted malonic semialdehyde reductase (rutE),
conserved protein (ybjX),
glutathione ABC transporter - periplasmic binding protein (gsiB),
conserved protein (ybiX),
YqjI DNA-binding transcriptional repressor,
periplasmic protein involved in nickel/cobalt efflux (rcnB),
predicted protein (ydiZ),
GadW DNA-binding transcriptional dual regulator,
fosmidomycin efflux transporter (fsr),
predicted DNA-binding transcriptional regulator LYSR-type (ygfI),
YebK DNA-binding transcriptional repressor,
N-acetylmannosamine kinase (nanK),
conserved protein (yhcH),
predicted transcriptional regulator (yhcF),
predicted outer membrane export usher protein (yraJ),
glycoside hydrolase (ygjK),
N-methyltryptophan oxidase (solA),
ethanol dehydrogenase / alcohol dehydrogenase (adhP),
predicted esterase (yjjU),
inner membrane protein - predicted transporter (yjiY),
hypothetical protein (yjiM),
KpLE2 phage-like element; predicted oxidoreductase (yjhC),
conserved protein (bsmA),
conserved protein (yeaD),
2,3-diketo-L-gulonate:Na+ symporter - periplasmic binding protein (yiaO),
2-keto-3-deoxygluconokinase (kdgK),
GadX DNA-binding transcriptional dual regulator,
dihydroxyacetone kinase subunit M (dhaM),
Fe2+ transporter FeoB,
nickel ABC transporter - ATP binding subunit (nikE),
putative outer membrane usher protein (yehB),
(R)-lactate / (S)-lactate / glycolate:H+ symporter LldP,
DNA gyrase inhibitor (sbmC),
formate dehydrogenase-O, α subunit (fdoG),
trehalose-6-phosphate synthase (otsA),
heme-containing peroxidase/deferrochelatase (efeB),
tyrosine lyase (thiH),
conserved protein (ycgB),
trehalose-6-phosphate hydrolase (treC),
4-aminobutyrate:H+ symporter (gabP),
D-mannonate dehydratase (uxuA),
P-loop guanosine triphosphatase (yjiA),
DNA-damage-inducible protein (dinD),
galactose ABC transporter - membrane subunit (mglC),
ribonucleoside hydrolase 3 (rihC),
L,D-transpeptidase LdtD,
adenosine deaminase (add),
putative structural protein (yciF),
catalase II (katE),
nitrate reductase Z, β subunit (narY),
phosphoribosylamine-glycine ligase (purD),
limit dextrin α-1,6-glucohydrolase (glgX),
fumarase B monomer (fumB),
periplasmic trehalase (treA),
predicted protein (yhaC),
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA),
β-ketoadipyl-CoA thiolase (paaJ),
phosphate ABC transporter - periplasmic binding protein (pstS),
inner membrane protein YibH,
putative transport protein, ABC superfamily - membrane component (ybhR),
conserved protein (yjeI),
maltose ABC transporter - periplasmic binding protein (malE),
glycolate oxidase, predicted FAD-linked subunit (glcD),
ferric enterobactin ABC transporter - periplasmic binding protein (fepB),
ferrous iron transport protein A (feoA),
formate dehydrogenase-O, γ subunit (fdoI),
predicted carboxysome structural protein (eutN),
conserved protein (elaB),
conserved outer membrane protein (yidQ),
conserved inner membrane protein (yiaA),
regulator for fimA (fimB),
conserved protein (yjiX),
predicted inner membrane protein (yohC),
OxyR DNA-binding transcriptional dual regulator,
GntR DNA-binding transcriptional repressor,
AllR DNA-binding transcriptional repressor,
LldR transcriptional repressor,
transcriptional dual regulator HU-α (HU-2) (hupA),
purine nucleoside phosphorylase (deoD),
choline:H+ symporter (betT),
arsenate reductase (arsC),
adenylosuccinate lyase (purB),
predicted lipoprotein (yceK),
predicted protein (ybiJ),
galactose ABC transporter - ATP binding subunit (mglA),
conserved protein (yedF),
pyruvate formate-lyase activating enzyme (pflA),
ferritin iron storage protein (ftnA),
outer membrane porin A (ompA),
outer membrane lipoprotein (lipocalin) (blc),
conserved protein (yfbU),
C4 dicarboxylate / orotate:H+ symporter (dctA),
HtpG monomer,
glycogen synthase (glgA),
flagellar P-ring protein FlgI,
deoxyribose-phosphate aldolase (deoC),
phosphopentomutase (deoB),
acetylglutamate kinase monomer (argB),
D-serine transporter (dsdX),
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB),
phosphoribosylglycinamide formyltransferase 1 (purN),
1,4-α-glucan branching enzyme (glgB),
phosphate ABC transporter - membrane subunit (pstA),
6-phosphofructokinase-2 monomer (pfkB),
OmpC monomer,
maltose ABC transporter - membrane subunit (malF),
D-serine ammonia-lyase (dsdA),
fumarate reductase flavoprotein (frdA),
toxic peptide TisB,
toxic inner membrane peptide DinQ,
predicted acyltransferase with acyl-CoA N-acyltransferase domain (yafP),
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system,
antitoxin of the YafO-YafN toxin-antitoxin system,
multifunctional nuclease Cas1,
EmrKY putative multidrug efflux transporter - membrane subunit (emrY),
EmrKY-TolC multidrug efflux transport system - membrane fusion protein,
β-phosphoglucomutase (ycjU),
predicted DNA-binding transcriptional regulator, LacI type (ycjW),
DLP12 prophage; predicted DNA-binding transcriptional regulator (ybcM),
phospholipid ABC transporter - MlaB subunit,
hypothetical protein (ykfM),
enterobactin efflux transporter EntS,
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC),
O-antigen flippase (rfbX),
predicted lyase containing HEAT-repeat (yibA),
conserved periplasmic protein (efeO),
glutamate-pyruvate aminotransferase (alaA),
predicted fimbrial-like adhesin protein (yadC),
predicted inner membrane protein regulated by LexA (ydjM),
toxin-like protein of the SOS response (symE),
IS150 conserved protein InsB (insK),
LexA-regulated protein (ybfE),
inhibitor of σS proteolysis (iraD),
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) (dinB),
endonuclease of nucleotide excision repair (cho),
endonuclease V (nfi),
regulatory protein RecX; inhibitor of RecA,
putative transport protein, ABC superfamily (modF),
ATP-dependent helicase (dinG),
DNA ligase (ligB),
RecG DNA helicase,
DNA ligase,
uracil-DNA glycosylase (ung),
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC,
SOS cell division inhibitor (sulA),
O6-alkylguanine-DNA-alkyltransferase (ogt),
DNA damage-inducible protein I (dinI),
endonuclease III (nth),
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC),
DNA repair; excision nuclease subunit B (uvrB),
protein interacts with RecR and possibly RecF proteins (recO),
DNA strand exchange and recombination protein with protease and nuclease activity (recA),
exonuclease III (xthA),
8-oxo-dGTP diphosphatase (mutT),
Ada DNA-binding transcriptional dual regulator,
protein used in recombination and DNA repair (recN),
formamidopyrimidine DNA glycosylase (mutM),
3-methyl-adenine DNA glycosylase I, constitutive (tag),
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB),
3-methyl-adenine DNA glycosylase II, inducible (alkA),
SOS mutagenesis and repair (umuC),
deoxyribodipyrimidine photolyase (photoreactivation) (phr)

Unification Links: GO:0006974

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Jan 1, 2002, biocyc12.