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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0006974 - cellular response to DNA damage stimulus

Synonyms: GO:0034984, cellular DNA damage response, DNA damage response, response to genotoxic stress

Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

Parent Classes:
GO:0033554 - cellular response to stress

Child Classes:
GO:0006281 - DNA repair (81) ,
GO:0031297 - replication fork processing (3)

Term Members:
RNA ligase (rtcB) ,
conserved protein (yggE) ,
AidB ,
endonuclease VIII (nei) ,
DNA recombination protein (radA) ,
MutL ,
DNA polymerase II (polB) ,
adenine glycosylase; G.C --> T.A transversions (mutY) ,
endodeoxyribonuclease RUS (Holliday junction resolvase) (rusA) ,
exonuclease X (exoX) ,
stationary phase mismatch/uracil DNA glycosylase (mug) ,
Holliday junction nuclease; resolution of structures; repair (ruvC) ,
branch migration of Holliday structures; repair helicase (ruvB) ,
branch migration of Holliday structures; repair (ruvA) ,
recombination and repair (recR) ,
ssDNA and dsDNA binding, ATP binding (recF) ,
endonuclease IV (nfo) ,
excision nuclease subunit A (uvrA) ,
DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway (vsr) ,
RecB ,
RecC ,
MutH ,
AlkB repair system for alkylated DNA and RNA ,
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease (polA) ,
transcription-repair coupling factor (mfd) ,
CP4-44 prophage; predicted disrupted hemin or colicin receptor (yoeE) ,
ssDNA-binding protein (ssb) ,
30S ribosome binding factor (rbfA) ,
predicted protein (yaaY) ,
RNA chaperone, involved in posttranscriptional control of ProP levels (proQ) ,
nucleotide binding protein (yajQ) ,
ATP-dependent dsDNA exonuclease (sbcC) ,
conserved protein, involved in DNA damage response (yfgI) ,
ATP-dependent DNA helicase (recQ) ,
homocysteine S-methyltransferase (mmuM) ,
predicted glucosyltransferase (yaiP) ,
L-glyceraldehyde 3-phosphate reductase (yghZ) ,
putative lipoprotein (yghG) ,
isopentenyl diphosphate isomerase (idi) ,
NAD(P)H-dependent FMN reductase (ssuE) ,
hydrogenase 4, component C (hyfC) ,
predicted periplasmic pilin chaperone (yqiH) ,
conserved protein (ydhQ) ,
aldehyde dehydrogenase: molybdenum cofactor-binding subunit (paoC) ,
hydrogenase 4, component F (hyfF) ,
tartronate semialdehyde reductase 2 (glxR) ,
predicted inner membrane protein (yqiJ) ,
predicted deoxygluconate dehydrogenase (ygcW) ,
conserved protein (yphB) ,
CP4-44 prophage; predicted disrupted hemin or colicin receptor (yoeA) ,
predicted sensory kinase in two-component regulatory system with YedW (yedV) ,
predicted phosphodiesterase (yoaD) ,
conserved protein (ydiQ) ,
predicted anaerobic sulfatase maturation enzyme (ydeM) ,
putrescine:H+ symporter PuuP ,
DNA-binding transcriptional regulator (yciT) ,
dihydroxyacetone kinase subunit K (dhaK) ,
predicted protein (ycfL) ,
protein involved in maturation of YcdX (ycdY) ,
predicted malonic semialdehyde reductase (rutE) ,
conserved protein (ybjX) ,
glutathione ABC transporter - periplasmic binding protein (gsiB) ,
conserved protein (ybiX) ,
YqjI DNA-binding transcriptional repressor ,
periplasmic protein involved in nickel/cobalt efflux (rcnB) ,
predicted protein (ydiZ) ,
GadW DNA-binding transcriptional dual regulator ,
fosmidomycin efflux transporter (fsr) ,
predicted DNA-binding transcriptional regulator LYSR-type (ygfI) ,
predicted DNA-binding transcriptional regulator (yebK) ,
N-acetylmannosamine kinase (nanK) ,
conserved protein (yhcH) ,
predicted transcriptional regulator (yhcF) ,
predicted outer membrane export usher protein (yraJ) ,
glycoside hydrolase (ygjK) ,
N-methyltryptophan oxidase (solA) ,
ethanol dehydrogenase / alcohol dehydrogenase (adhP) ,
predicted esterase (yjjU) ,
inner membrane protein - predicted transporter (yjiY) ,
hypothetical protein (yjiM) ,
KpLE2 phage-like element; predicted oxidoreductase (yjhC) ,
conserved protein (bsmA) ,
conserved protein (yeaD) ,
AldB ,
2,3-diketo-L-gulonate:Na+ symporter - periplasmic binding protein (yiaO) ,
2-keto-3-deoxygluconokinase (kdgK) ,
GadX DNA-binding transcriptional dual regulator ,
dihydroxyacetone kinase subunit M (dhaM) ,
Fe2+ transporter FeoB ,
nickel ABC transporter - ATP binding subunit (nikE) ,
putative outer membrane usher protein (yehB) ,
(R)-lactate / (S)-lactate / glycolate:H+ symporter LldP ,
DNA gyrase inhibitor (sbmC) ,
formate dehydrogenase-O, α subunit (fdoG) ,
trehalose-6-phosphate synthase (otsA) ,
heme-containing peroxidase/deferrochelatase (efeB) ,
tyrosine lyase (thiH) ,
conserved protein (ycgB) ,
trehalose-6-phosphate hydrolase (treC) ,
4-aminobutyrate:H+ symporter (gabP) ,
D-mannonate dehydratase (uxuA) ,
P-loop guanosine triphosphatase (yjiA) ,
MutS ,
EmrE ,
DNA-damage-inducible protein (dinD) ,
galactose ABC transporter - membrane subunit (mglC) ,
ribonucleoside hydrolase 3 (rihC) ,
L,D-transpeptidase YcbB ,
adenosine deaminase (add) ,
putative structural protein (yciF) ,
catalase II (katE) ,
nitrate reductase Z, β subunit (narY) ,
NadE ,
phosphoribosylamine-glycine ligase (purD) ,
glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase (glgX) ,
fumarase B monomer (fumB) ,
periplasmic trehalase (treA) ,
Udp ,
predicted protein (yhaC) ,
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (hisA) ,
β-ketoadipyl-CoA thiolase (paaJ) ,
phosphate ABC transporter - periplasmic binding protein (pstS) ,
putative membrane protein (yibH) ,
YbhR ,
NarX ,
conserved protein (yjeI) ,
maltose ABC transporter - periplasmic binding protein (malE) ,
glycolate oxidase, predicted FAD-linked subunit (glcD) ,
ferric enterobactin ABC transporter - periplasmic binding protein (fepB) ,
ferrous iron transport protein A (feoA) ,
formate dehydrogenase-O, γ subunit (fdoI) ,
predicted carboxysome structural protein (eutN) ,
conserved protein (elaB) ,
CobU ,
conserved outer membrane protein (yidQ) ,
conserved inner membrane protein (yiaA) ,
regulator for fimA (fimB) ,
conserved protein (yjiX) ,
predicted inner membrane protein (yohC) ,
OxyR DNA-binding transcriptional dual regulator ,
GntR DNA-binding transcriptional repressor ,
AllR DNA-binding transcriptional repressor ,
LldR transcriptional repressor ,
transcriptional dual regulator HU-α (HU-2) (hupA) ,
purine nucleoside phosphorylase (deoD) ,
choline:H+ symporter (betT) ,
arsenate reductase (arsC) ,
adenylosuccinate lyase (purB) ,
predicted lipoprotein (yceK) ,
predicted protein (ybiJ) ,
galactose ABC transporter - ATP binding subunit (mglA) ,
conserved protein (yedF) ,
Asd ,
pyruvate formate-lyase activating enzyme (pflA) ,
ferritin iron storage protein (ftnA) ,
DnaN ,
outer membrane protein A (ompA) ,
Blc outer membrane lipoprotein (lipocalin) ,
conserved protein (yfbU) ,
C4 dicarboxylate / orotate:H+ symporter (dctA) ,
PurA ,
HtpG monomer ,
glycogen synthase (glgA) ,
flagellar P-ring protein FlgI ,
deoxyribose-phosphate aldolase (deoC) ,
phosphopentomutase (deoB) ,
GlpK ,
acetylglutamate kinase monomer (argB) ,
NagE ,
D-serine transporter (dsdX) ,
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase (cpdB) ,
phosphoribosylglycinamide formyltransferase 1 (purN) ,
1,4-α-glucan branching enzyme (glgB) ,
phosphate ABC transporter - membrane subunit (pstA) ,
DeoA ,
6-phosphofructokinase-2 monomer (pfkB) ,
OmpC ,
ArgF ,
RecD ,
LamB ,
maltose ABC transporter - membrane subunit (malF) ,
AsnA ,
D-serine ammonia-lyase (dsdA) ,
fumarate reductase flavoprotein (frdA) ,
toxic peptide TisB ,
toxic inner membrane peptide DinQ ,
predicted acyltransferase with acyl-CoA N-acyltransferase domain (yafP) ,
ribosome-dependent mRNA interferase, toxin of the YafO-YafN toxin-antitoxin system ,
antitoxin of the YafO-YafN toxin-antitoxin system ,
multifunctional nuclease (cas1) ,
EmrKY putative multidrug efflux transporter - membrane subunit (emrY) ,
EmrKY-TolC multidrug efflux transport system - membrane fusion protein ,
β-phosphoglucomutase (ycjU) ,
predicted DNA-binding transcriptional regulator, LacI type (ycjW) ,
DLP12 prophage; predicted DNA-binding transcriptional regulator (ybcM) ,
MlaB ,
hypothetical protein (ykfM) ,
enterobactin efflux transporter EntS ,
dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC) ,
O-antigen flippase (rfbX) ,
predicted lyase containing HEAT-repeat (yibA) ,
conserved periplasmic protein (efeO) ,
glutamate-pyruvate aminotransferase (alaA) ,
predicted fimbrial-like adhesin protein (yadC) ,
HokE ,
predicted inner membrane protein regulated by LexA (ydjM) ,
toxin-like protein of the SOS response (symE) ,
IS150 conserved protein InsB (insK) ,
LexA-regulated protein (ybfE) ,
inhibitor of σS proteolysis (iraD) ,
DNA polymerase IV (Y-family DNA polymerase; translesion DNA synthesis) (dinB) ,
endonuclease of nucleotide excision repair (cho) ,
endonuclease V (deoxyinosine 3'-endonuclease) (nfi) ,
regulatory protein RecX; inhibitor of RecA ,
ModF ,
ATP-dependent helicase (dinG) ,
DNA ligase (ligB) ,
RecG DNA helicase ,
DNA ligase ,
uracil-DNA glycosylase (ung) ,
SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC ,
SOS cell division inhibitor (sulA) ,
O6-alkylguanine-DNA-alkyltransferase (ogt) ,
DNA damage-inducible protein I (dinI) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
predicted transcription antitermination factor (yqgF) ,
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC) ,
DNA repair; excision nuclease subunit B (uvrB) ,
protein interacts with RecR and possibly RecF proteins (recO) ,
DNA strand exchange and recombination protein with protease and nuclease activity (recA) ,
LexA ,
exonuclease III (xthA) ,
8-oxo-dGTP diphosphatase (mutT) ,
Ada DNA-binding transcriptional dual regulator ,
protein used in recombination and DNA repair (recN) ,
formamidopyrimidine DNA glycosylase (mutM) ,
3-methyl-adenine DNA glycosylase I, constitutive (tag) ,
exonuclease I, 3' --> 5' specific; deoxyribophosphodiesterase (sbcB) ,
3-methyl-adenine DNA glycosylase II, inducible (alkA) ,
SOS mutagenesis and repair (umuC) ,
UvrD ,
deoxyribodipyrimidine photolyase (photoreactivation) (phr)

Unification Links: GO:0006974


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13A.