Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0008237 - metallopeptidase activity

Synonyms: metalloprotease activity, metalloproteinase activity

Definition: Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Parent Classes:
GO:0070011 - peptidase activity, acting on L-amino acid peptides

Child Classes:
GO:0004222 - metalloendopeptidase activity (14) ,
GO:0008235 - metalloexopeptidase activity (9)

Term Members:
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (tldD) ,
protease involved in Microcin B17 maturation and in sensitivity to the DNA gyrase inhibitor LetD (pmbA) ,
chaperone/protease involved in the maintenance of OM integrity (bepA) ,
D-Ala-D-Ala dipeptidase (ddpX) ,
heat shock protein, integral membrane protein (htpX) ,
RseP zinc protease, signal peptide peptidase ,
Mlc titration factor (mtfA) ,
ArgE ,
N-succinyl-L-diaminopimelate desuccinylase subunit (dapE) ,
KpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain (sgcX) ,
frv operon protein (frvX) ,
protein involved in threonylcarbamoyladenosine biosynthesis (tsaB) ,
broad-specificity exoaminopeptidase (ypdE) ,
predicted peptidase (ygeY) ,
predicted peptidase with chaperone function (ycaL) ,
IadA ,
predicted zinc-dependent peptidase (yhjJ) ,
putative zinc peptidase (pqqL) ,
peptidase T ,
oligopeptidase A (prlC) ,
outer membrane metallopeptidase (loiP) ,
dipeptidyl carboxypeptidase II (dcp) ,
Xaa-Pro dipeptidase (pepQ) ,
peptidase D (pepD) ,
PepP ,
MepA ,
murein DD-endopeptidase MepM ,
ATP-dependent zinc metalloprotease FtsH ,
protease III (ptrA) ,
aminopeptidase N (pepN)

Unification Links: GO:0008237

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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