Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0008657 - DNA topoisomerase (ATP-hydrolyzing) inhibitor activity

Synonyms: DNA gyrase inhibitor activity

Definition: Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Parent Classes:
GO:0072586 - DNA topoisomerase (ATP-hydrolyzing) regulator activity,
GO:0042030 - ATPase inhibitor activity

Term Members:
DNA gyrase inhibitor (sbmC),
DNA gyrase inhibitor YacG

Unification Links: GO:0008657

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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