Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0009380 - excinuclease repair complex

Synonyms: excinuclease ABC complex, UvrABC excinuclease complex

Definition: Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap.

Parent Classes:
GO:1990391 - DNA repair complex,
GO:1902494 - catalytic complex,
GO:0044424 - intracellular part

Term Members:
DNA repair; excision nuclease subunit B (uvrB),
excinuclease ABC, subunit C; repair of UV damage to DNA (uvrC),
excision nuclease subunit A (uvrA)

Unification Links: GO:0009380

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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