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Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0016829 - lyase activity

Definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Summary:
Note that enzymes of class EC:4.99.-.- should also be annotated to this term.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0004325 - ferrochelatase activity (2) ,
GO:0016830 - carbon-carbon lyase activity (75) ,
GO:0016835 - carbon-oxygen lyase activity (73) ,
GO:0016840 - carbon-nitrogen lyase activity (17) ,
GO:0016846 - carbon-sulfur lyase activity (11) ,
GO:0016848 - carbon-halide lyase activity (2) ,
GO:0016849 - phosphorus-oxygen lyase activity (2)

Term Members:
ureidoglycolate lyase (allA) ,
D-galactonate dehydratase (dgoD) ,
2-oxo-3-deoxygalactonate 6-phosphate aldolase (dgoA) ,
Fsa (fsaA) ,
MhpD ,
2-methylisocitrate lyase (prpB) ,
oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (paaZ) ,
2-methylcitrate dehydratase (prpD) ,
L-rhamnonate dehydratase (yfaW) ,
N-acetylmuramic acid 6-phosphate etherase (murQ) ,
2-keto-3-deoxy-L-rhamnonate aldolase (yfaU) ,
D-cysteine desulfhydrase (dcyD) ,
predicted 2,3-dehydroadipyl-CoA hydratase (paaF) ,
LtaE ,
glutamate decarboxylase B subunit (gadB) ,
glutamate decarboxylase A subunit (gadA) ,
2,3-diaminopropionate ammonia-lyase (ygeX) ,
6-carboxy-5,6,7,8-tetrahydropterin synthase (queD) ,
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase monomer (ispF) ,
carbonic anhydrase 2 monomer (can) ,
LdcC ,
methylmalonyl-CoA decarboxylase (scpB) ,
4-hydroxy-2-ketovalerate aldolase (mhpE) ,
endonuclease VIII (nei) ,
S-ribosylhomocysteine lyase (luxS) ,
L-serine deaminase III (tdcG) ,
D-altronate dehydratase (uxaA) ,
galactarate dehydratase (garD) ,
3-keto-L-gulonate 6-phosphate decarboxylase (ulaD) ,
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH) ,
bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase (acnB) ,
fructose 6-phosphate aldolase 2 (fsaB) ,
rhamnulose-1-phosphate aldolase monomer (rhaD) ,
NAD(P)HX epimerase / NAD(P)HX dehydratase (yjeF) ,
L-serine deaminase II (sdaB) ,
uroporphyrinogen decarboxylase (hemE) ,
o-succinylbenzoate synthase (menC) ,
Adi (adiA) ,
pabC ,
dTDP-glucose 4,6-dehydratase 2 (rffG) ,
chorismate lyase (ubiC) ,
aconitate hydratase 1 (acnA) ,
D-mannonate dehydratase (uxuA) ,
ferrochelatase (hemH) ,
GarL ,
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon (malY) ,
phosphoenolpyruvate carboxykinase (ATP) (pck) ,
SpeA ,
ornithine decarboxylase, biosynthetic (speC) ,
L-serine deaminase I (sdaA) ,
fumarase B monomer (fumB) ,
argininosuccinate lyase (argH) ,
TdcB ,
3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG (ubiX) ,
oxalyl-CoA decarboxylase (oxc) ,
D-glucarate dehydratase (gudD) ,
glyoxylate carboligase (gcl) ,
phosphogluconate dehydratase (edd) ,
porphobilinogen synthase (hemB) ,
glyoxalase I (gloA) ,
AspA ,
fumarase A monomer ,
dihydroneopterin aldolase (folB) ,
MenB ,
Dfp ,
O-acetylserine sulfhydrylase A (cysK) ,
carbonic anhydrase monomer (cynT) ,
adenylosuccinate lyase (purB) ,
FucA ,
KbaY ,
fructose bisphosphate aldolase monomer (fbaA) ,
3-octaprenyl-4-hydroxybenzoate carboxy-lyase monomer (ubiD) ,
PheA ,
CadA ,
isocitrate lyase monomer (aceA) ,
Eda ,
phosphatidylserine decarboxylase, proenzyme (psd) ,
tryptophan synthase, β subunit (trpB) ,
tryptophanase (tnaA) ,
3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB) ,
adenosylmethionine decarboxylase, proenzyme (speD) ,
methylglyoxal synthase (mgsA) ,
FabZ ,
Eno ,
N-acetylneuraminate lyase (nanA) ,
4-hydroxy-tetrahydrodipicolinate synthase (dapA) ,
deoxyribose-phosphate aldolase (deoC) ,
LeuC ,
PyrF ,
3-dehydroquinate synthase (aroB) ,
HisB ,
MetC ,
IlvD ,
formamidopyrimidine DNA glycosylase (mutM) ,
fumarase C monomer (fumC) ,
IlvA ,
adenylate cyclase (cyaA) ,
threonine synthase (thrC) ,
D-serine ammonia-lyase (dsdA) ,
deoxyribodipyrimidine photolyase (photoreactivation) (phr) ,
indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) ,
anthranilate synthase component II (trpD) ,
anthranilate synthase component I (trpE) ,
LysA ,
cyanase monomer (cynS) ,
molybdopterin biosynthesis protein A (moaA) ,
Cys-tRNAPro and Cys-tRNACys deacylase (ybaK) ,
conserved protein (queE) ,
glyoxalase III, Hsp31 molecular chaperone (hchA) ,
lytic murein transglycosylase E (emtA) ,
GatY ,
tyrosine lyase (thiH) ,
carbon-phosphorous lyase (phnJ) ,
HMP-P synthase (thiC) ,
membrane-bound lytic murein transglycosylase C (mltC) ,
membrane-bound lytic murein transglycosylase F (mltF) ,
soluble lytic murein transglycosylase (slt) ,
membrane-bound lytic murein transglycosylase D (mltD) ,
membrane-bound lytic murein transglycosylase B (mltB) ,
membrane-bound lytic murein transglycosylase A (mltA) ,
cysteine sulfinate desulfinase (csdA) ,
glucarate dehydratase-related protein (gudX) ,
CP4-6 prophage; D-xylonate dehydratase (yagF) ,
predicted ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) (paaG) ,
L-cysteine desulfurase (sufS) ,
FadJ monomer ,
predicted class I aldolase (lsrF) ,
citrate lyase, citrate-ACP transferase α subunit (citF) ,
CP4-6 prophage; probable 2-keto-3-deoxygluconate aldolase (yagE) ,
imidazole glycerol phosphate synthase, HisF subunit ,
KpLE2 phage-like element; 2-dehydro-3-deoxy-D-pentonate aldolase (yjhH) ,
KpLE2 phage-like element; D-xylonate dehydratase (yjhG) ,
dTDP-glucose 4,6-dehydratase (rfbB) ,
3-keto-L-gulonate 6-phosphate decarboxylase (sgbH) ,
6-deoxy-6-sulfofructose-1-phosphate aldolase (yihT) ,
crotonobetainyl-CoA hydratase (caiD) ,
LeuD ,
ornithine decarboxylase, degradative (speF) ,
dodecenoyl-CoA δ-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase (fadB) ,
ethanolamine ammonia-lyase, β subunit (eutC) ,
AroC ,
ethanolamine ammonia-lyase, α subunit (eutB) ,
CysG ,
GDP-mannose 4,6-dehydratase (gmd) ,
L-tartrate dehydratase, β subunit (ttdB) ,
endonuclease III; specific for apurinic and/or apyrimidinic sites (nth) ,
citrate lyase, citryl-ACP lyase β subunit (citE) ,
fructose bisphosphate aldolase monomer (fbaB) ,
tryptophan synthase, α subunit (trpA) ,
PanD proenzyme, π protein ,
FabA ,
uroporphyrinogen III synthase (hemD) ,
L-tartrate dehydratase, α subunit (ttdA) ,
AroD ,
Ppc

Unification Links: GO:0016829


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 28, 2014, BIOCYC15B.