Escherichia coli K-12 substr. MG1655 Gene-Ontology-Terms Class: GO:0016874 - ligase activity

Synonyms: synthetase activity

Definition: Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.

Parent Classes:
GO:0003824 - catalytic activity

Child Classes:
GO:0008754 - O antigen ligase activity (1),
GO:0016875 - ligase activity, forming carbon-oxygen bonds (27),
GO:0016877 - ligase activity, forming carbon-sulfur bonds (17),
GO:0016879 - ligase activity, forming carbon-nitrogen bonds (48),
GO:0016885 - ligase activity, forming carbon-carbon bonds (5),
GO:0016886 - ligase activity, forming phosphoric ester bonds (7),
GO:0051002 - ligase activity, forming nitrogen-metal bonds (1)

Term Members:
EntB monomer,
5-formyltetrahydrofolate cyclo-ligase (fau),
ribosomal protein S6 modification protein (rimK),
tRNA threonylcarbamoyladenosine dehydratase (tcdA),
glutamate-putrescine ligase (puuA),
propionyl-CoA synthetase (prpE),
carboxylate-amine ligase (ybdK),
phenylacetate-CoA ligase (paaK),
histidyl-tRNA synthetase (hisS),
tRNAIle-lysidine synthetase (tilS),
RNA ligase (rtcB),
RNA 3'-terminal phosphate cyclase (rtcA),
short chain acyl-CoA synthetase (fadK),
UDP-N-acetylmuramate:L-alanyl-γ-D-glutamyl-meso-diaminoheptanedioate-D-alanine ligase [multifunctional] (mpl),
o-succinylbenzoate-CoA ligase (menE),
pantothenate synthetase monomer (panC),
carnitine-CoA ligase (caiC),
2-acylglycerophosphoethanolamine acyltransferase / acyl-ACP synthetase (aas),
acetyl-CoA synthetase (AMP-forming) (acs),
O-antigen ligase (waaL),
DNA ligase (ligB),
UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase (murE),
aspartyl-tRNA synthetase (aspS),
cysteinyl-tRNA synthetase (cysS),
UDP-N-acetylmuramate-alanine ligase (murC),
prolyl-tRNA synthetase (proS),
phosphoribosylamine-glycine ligase (purD),
phosphoribosylformylglycinamide synthetase (purL),
DNA ligase,
UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (murD),
dethiobiotin synthetase monomer (bioD),
D-alanyl-D-alanine-adding enzyme (murF),
acetyl-CoA carboxyltransferase, β subunit (accD),
glutamine synthetase (glnA),
threonyl-tRNA synthetase (thrS),
seryl-tRNA synthetase (serS),
succinyl-CoA synthetase, β subunit,
γ-glutamate-cysteine ligase (gshA),
D-alanine-D-alanine ligase A (ddlA),
N5-carboxyaminoimidazole ribonucleotide synthetase monomer (purK),
bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase (folC),
D-alanine-D-alanine ligase B (ddlB),
leucyl-tRNA synthetase (leuS),
bifunctional biotin-[acetyl-CoA-carboxylase] ligase and transcriptional repressor (birA),
glutamyl-tRNA synthetase (gltX),
glutathione synthetase monomer (gshB),
GMP synthetase (guaA),
carbamoyl phosphate synthetase, β chain,
glutaminyl-tRNA synthetase (glnS),
alanyl-tRNA synthetase (alaS),
predicted synthetase/amidase with ATPase activity (yjfC),
nicotinate phosphoribosyltransferase (pncB),
predicted enzyme with ATPase activity (ygiC),
EF-P-lysine lysyltransferase (epmA),
asparaginyl-tRNA synthetase (asnS),
7-cyano-7-deazaguanine synthase (queC),
lysyl-tRNA synthetase (lysU),
citrate lyase synthetase (citC),
glutamyl-Q tRNAAsp synthetase (gluQ),
arginyl-tRNA synthetase (argS),
apo-serine activating enzyme (entF),
tyrosyl-tRNA synthetase (tyrS),
succinyl-CoA synthetase, α subunit (sucD),
acetyl-CoA carboxyltransferase, α subunit (accA),
lysyl tRNA synthetase (LysRSs), constitutive (lysS),
carbamoyl phosphate synthetase, α chain (carA),
predicted dethiobiotin synthetase (ynfK),
phenylalanyl-tRNA synthetase α-chain (pheS),
phenylalanyl-tRNA synthetase β-chain (pheT),
valyl-tRNA synthetase (valS),
glycyl-tRNA synthetase, β subunit (glyS),
glycyl-tRNA synthetase, α subunit (glyQ),
methionyl-tRNA synthetase (metG),
isoleucyl-tRNA synthetase (ileS),
tryptophanyl-tRNA synthetase (trpS)

Unification Links: GO:0016874

Relationship Links: ENZYME:RELATED-TO:6, Reactome:RELATED-TO:REACT_115603, Reactome:RELATED-TO:REACT_116018

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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