Escherichia coli K-12 substr. MG1655 Compound Class: a long-chain acyl-CoA

Synonyms: a fatty acyl-CoA, fatty acyl CoA-, acyl-CoA, a fatty acyl CoA, long-chain acyl-CoA

Superclasses: an estera thioestera coenzyme A-activated compoundan acyl-CoA

Acyl-CoAs are oxoacids that have been activated by coenzyme A. They are often classified by the length of their acyl moiety.

Medium-chain acyl-CoAs are derived from fatty acids with aliphatic chains of 6-12 carbons.

Long-chain acyl-CoAs are derived from fatty acids with aliphatic chains of 13-22 carbons.

Very-long-chain fatty acyl-CoAs are derived from fatty acids with aliphatic chains of 23 carbons or longer.

a long-chain acyl-CoA compound structure

Child Classes: a hexadecenoyl-CoA (n-C16:1CoA) (1), a long-chain 2,3,4-saturated fatty acyl CoA (6), a [glycerolipid]-(9Z,12Z)-hexadeca-9,12-dienoate (0), an ω-hydroxy long-chain fatty acyl-CoA (0)

Component of: FadR-acyl-CoA

Citations: [Lubert]

SMILES: CC(C)(C(O)C(=O)NCCC(=O)NCCSC(=O)[R])COP(=O)(OP(=O)(OCC1(C(OP([O-])(=O)[O-])C(O)C(O1)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-]

Unification Links: ChEBI:33184, KEGG:C02843

Reactions known to consume the compound:

CDP-diacylglycerol biosynthesis I :
a long-chain acyl-CoA + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + coenzyme A
a long-chain acyl-CoA + a 1-acyl-sn-glycerol 3-phosphate → a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A

Not in pathways:
an acyl-CoA + H2O → a carboxylate + coenzyme A + H+

In Reactions of unknown directionality:

Not in pathways:
FadR + an acyl-CoA = FadR-acyl-CoA

Enzymes inhibited by a long-chain acyl-CoA, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: glycerol-3-phosphate dehydrogenase [Edgar79]

Imported from HumanCyc 21-Mar-2013 by Brito D, SRI International
Imported from MetaCyc 23-May-2013 by Paley S, SRI International

Transcription Units regulated by related protein FadR-acyl-CoA (1 total):

Transcription-unit diagram


Edgar79: Edgar JR, Bell RM (1979). "Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Palmitoyl-CoA inhibition of the biosynthetic sn-glycerol-3-phosphate dehydrogenase." J Biol Chem 1979;254(4);1016-21. PMID: 368067

Lubert: Lubert Stryer "Biochemistry." ISBN 0-7167-1226-1.

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC11A.