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Escherichia coli K-12 substr. MG1655 Class: a protein

Synonyms: Protein

This is a higher level class that contains all proteins, be they monomers or multimers.

This frame should NOT be used as a substrate in any reactions. For reactions, use the class a protein.

Child Classes: a 4-amino-2-methyl-5-phosphomethylpyrimidine synthase (0), a carboxyadenylated CysO sulfur-carrier protein (0), a CysO sulfur-carrier protein (0), a fructose-bisphosphate aldolase (0), a glycoprotein (0), a hemoprotein (1), a microsomal-membrane protein (0), a modified protein (173), a non-ribosomal peptide synthase (1), a peroxiredoxin (0), a polypeptide (4547), a protein (0), a protein complex (1079), a protein sulfur acceptor (3), a protein with LPXTG motif (0), a protein with NXTN motif (0), a protein-DNA complex (0), a protein-RNA complex (8), a protein-small molecule complex (106), a radical-S-adenosyl-L-methionine-dependent enzyme (1), a receptor protein (0), a sigma factor (7), a thiocarboxylated [CysO sulfur-carrier protein] (0), a transporter (474), a [CysO sulfur-carrier protein]-S-L-cysteine (0), all acyl-carrier proteins (5), an α,α-trehalose-phosphate synthase (0), an apo-iron-sulfur protein (0), an oxyhemoglobin (0), an [Fe-S cluster biosynthesis chaperone] (1), an [Fe-S cluster biosynthesis chaperone]-ATP (0), an [Fe-S cluster biosynthesis co-chaperone] (1), an [Fe-S] cluster scaffold protein (0), an [FeS cluster biosynthesis chaperone]-ADP (0), casein (0)


Baier97: Baier M, Dietz KJ (1997). "The plant 2-Cys peroxiredoxin BAS1 is a nuclear-encoded chloroplast protein: its expressional regulation, phylogenetic origin, and implications for its specific physiological function in plants." Plant J 12(1);179-90. PMID: 9263459

Bertini03: Bertini I, Cowan JA, Del Bianco C, Luchinat C, Mansy SS (2003). "Thermotoga maritima IscU. Structural characterization and dynamics of a new class of metallochaperone." J Mol Biol 331(4);907-24. PMID: 12909018

Brehelin03: Brehelin C, Meyer EH, de Souris JP, Bonnard G, Meyer Y (2003). "Resemblance and dissemblance of Arabidopsis type II peroxiredoxins: similar sequences for divergent gene expression, protein localization, and activity." Plant Physiol 132(4);2045-57. PMID: 12913160

Burns05: Burns KE, Baumgart S, Dorrestein PC, Zhai H, McLafferty FW, Begley TP (2005). "Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis." J Am Chem Soc 127(33);11602-3. PMID: 16104727

Byers07: Byers DM, Gong H (2007). "Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family." Biochem Cell Biol 85(6);649-62. PMID: 18059524

Coquille12: Coquille S, Roux C, Fitzpatrick TB, Thore S (2012). "The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase." J Biol Chem 287(50);42333-43. PMID: 23048037

Finking04: Finking R, Marahiel MA (2004). "Biosynthesis of nonribosomal peptides1." Annu Rev Microbiol 58;453-88. PMID: 15487945

Kim09a: Kim JH, Fuzery AK, Tonelli M, Ta DT, Westler WM, Vickery LE, Markley JL (2009). "Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB." Biochemistry 48(26);6062-71. PMID: 19492851

Kim12: Kim JH, Tonelli M, Markley JL (2012). "Disordered form of the scaffold protein IscU is the substrate for iron-sulfur cluster assembly on cysteine desulfurase." Proc Natl Acad Sci U S A 109(2);454-9. PMID: 22203963

Kong00: Kong W, Shiota S, Shi Y, Nakayama H, Nakayama K (2000). "A novel peroxiredoxin of the plant Sedum lineare is a homologue of Escherichia coli bacterioferritin co-migratory protein (Bcp)." Biochem J 351(Pt 1);107-14. PMID: 10998352

Mansy04: Mansy SS, Wu SP, Cowan JA (2004). "Iron-sulfur cluster biosynthesis: biochemical characterization of the conformational dynamics of Thermotoga maritima IscU and the relevance for cellular cluster assembly." J Biol Chem 279(11);10469-75. PMID: 14688265

Markley13: Markley JL, Kim JH, Dai Z, Bothe JR, Cai K, Frederick RO, Tonelli M (2013). "Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery." FEBS Lett. PMID: 23333622

Silberg01: Silberg JJ, Hoff KG, Tapley TL, Vickery LE (2001). "The Fe/S assembly protein IscU behaves as a substrate for the molecular chaperone Hsc66 from Escherichia coli." J Biol Chem 276(3);1696-700. PMID: 11053447

Silberg04: Silberg JJ, Tapley TL, Hoff KG, Vickery LE (2004). "Regulation of the HscA ATPase reaction cycle by the co-chaperone HscB and the iron-sulfur cluster assembly protein IscU." J Biol Chem 279(52):53924-31. PMID: 15485839

Stacy96: Stacy RA, Munthe E, Steinum T, Sharma B, Aalen RB (1996). "A peroxiredoxin antioxidant is encoded by a dormancy-related gene, Per1, expressed during late development in the aleurone and embryo of barley grains." Plant Mol Biol 31(6);1205-16. PMID: 8914536

Stork05: Stork T, Michel KP, Pistorius EK, Dietz KJ (2005). "Bioinformatic analysis of the genomes of the cyanobacteria Synechocystis sp. PCC 6803 and Synechococcus elongatus PCC 7942 for the presence of peroxiredoxins and their transcript regulation under stress." J Exp Bot 56(422);3193-206. PMID: 16284092

Welker06: Welker M, von Dohren H (2006). "Cyanobacterial peptides - nature's own combinatorial biosynthesis." FEMS Microbiol Rev 30(4);530-63. PMID: 16774586

Wood03: Wood ZA, Poole LB, Karplus PA (2003). "Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling." Science 300(5619);650-3. PMID: 12714747

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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