Escherichia coli K-12 substr. MG1655 Compound: 2-thiouridine

Synonyms: s2U

Superclasses: a nucleic acid componenta base derivative
an organic heterocyclic compoundan organonitrogen heterocyclic compounda diazinea pyrimidine

Summary from MetaCyc:
Thionucleosides are uniquely present in tRNA. In many organisms, tRNA specific for Lys, Glu, and Gln contain hypermodified 2-thiouridine (s2U) derivatives.

Citations: [Kambampati03]

Chemical Formula: C9H12N2O5S

Molecular Weight: 260.26 Daltons

Monoisotopic Molecular Weight: 260.0466921961 Daltons

2-thiouridine compound structure

SMILES: C1(=CN(C(=S)NC(=O)1)C2(OC(CO)C(O)C(O)2))

InChI: InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1


Unification Links: ChEBI:60731, ChemSpider:2300457, PubChem:3036443

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -149.88


Kambampati03: Kambampati R, Lauhon CT (2003). "MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli." Biochemistry 42(4);1109-17. PMID: 12549933

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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