Escherichia coli K-12 substr. MG1655 Compound Class: a [3Fe-4S] iron-sulfur cluster

Synonyms: a Fe3S4 cluster, a Fe3S4 center, Fe3S4, a Fe3S4 iron-sulfur center, a Fe3S4 iron-sulfur cluster, a [3Fe-4S] iron-sulfur center, [3Fe-4S]

Superclasses: a cofactora prosthetic groupa metal-sulfur clusteran iron-sulfur cluster

Iron-sulfur clusters are prosthetic groups of many proteins, which function as intracellular electron carriers with a low reduction potential. In addition to their roles in electron transfer reactions, iron-sulfur clusters are also known to participate in the activation of substrates, the stabilization of radicals and structures, the protection of proteins from enzymes and the storage of iron and sulfur. In addition, they act as sensors of iron, dioxygen, the superoxide ion, and possibly nitric oxide, and participate in gene expression [Park06a].

a [3Fe-4S] iron-sulfur cluster compound structure

Chemical Formula: S4Fe3

Molecular Weight: 295.78 Daltons

Monoisotopic Molecular Weight: 295.69310906 Daltons

SMILES: [Fe]12(S[Fe]3(S1[Fe](S2)S3))

InChI: InChI=1S/3Fe.4S


Unification Links: ChEBI:47402, ChemSpider:4911357, PubChem:6398952

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): 2.16

This compound has been characterized as a cofactor or prosthetic group of the following enzymes: hydrogen:menaquinone oxidoreductase, succinate:quinone oxidoreductase, menaquinol:nitrate oxidoreductase, fumarate reductase


Park06a: Park YJ, Yoo CB, Choi SY, Lee HB (2006). "Purifications and characterizations of a ferredoxin and its related 2-oxoacid:ferredoxin oxidoreductase from the hyperthermophilic archaeon, Sulfolobus solfataricus P1." J Biochem Mol Biol 39(1);46-54. PMID: 16466637

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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
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