Synonyms: Fe3S4 cluster, Fe3S4 center, Fe3S4, Fe3S4 iron-sulfur center, Fe3S4 iron-sulfur cluster, [3Fe-4S] iron-sulfur center, [3Fe-4S]
|Superclasses:||a cofactor → a prosthetic group → an iron-sulfur cluster|
Iron-sulfur clusters are prosthetic groups of many proteins, which function as intracellular electron carriers with a low reduction potential. In addition to their roles in electron transfer reactions, iron-sulfur clusters are also known to participate in the activation of substrates, the stabilization of radicals and structures, the protection of proteins from enzymes and the storage of iron and sulfur. In addition, they act as sensors of iron, dioxygen, the superoxide ion, and possibly nitric oxide, and participate in gene expression [Park06].
This type of iron-sulfur clusters are very similar to an a [4Fe-4S] iron-sulfur cluster, missing one of the iron atoms.
Chemical Formula: S4Fe3
Molecular Weight: 295.78 Daltons
Monoisotopic Molecular Weight: 295.69310906 Daltons
Standard Gibbs Free Energy of Change Formation (ΔfG'° in kcal/mol): 2.16
Park06: Park YJ, Yoo CB, Choi SY, Lee HB (2006). "Purifications and characterizations of a ferredoxin and its related 2-oxoacid:ferredoxin oxidoreductase from the hyperthermophilic archaeon, Sulfolobus solfataricus P1." J Biochem Mol Biol 39(1);46-54. PMID: 16466637
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493