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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Escherichia coli K-12 substr. MG1655 Compound: acetaldehyde

Synonyms: acetic aldehyde, ethanal, aldehyde, ethyl aldehyde

Superclasses: an aldehyde or ketone an aldehyde an n-alkanal

Chemical Formula: C2H4O

Molecular Weight: 44.053 Daltons

Monoisotopic Molecular Weight: 44.026214750499996 Daltons

SMILES: C[CH]=O

InChI: InChI=1S/C2H4O/c1-2-3/h2H,1H3

InChIKey: InChIKey=IKHGUXGNUITLKF-UHFFFAOYSA-N

Unification Links: CAS:75-07-0 , ChEBI:15343 , ChemSpider:172 , HMDB:HMDB00990 , IAF1260:33792 , KEGG:C00084 , MetaboLights:MTBLC15343 , PubChem:177 , UMBBD-Compounds:c0160

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -33.4

Reactions known to consume the compound:

Not in pathways:
acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+
pyruvate + acetaldehyde + H+ → acetoin + CO2


an aldehyde + NADP+ + H2O → a carboxylate + NADPH + 2 H+

Reactions known to produce the compound:

ethanolamine utilization :
ethanolamine → ammonium + acetaldehyde

preQ0 biosynthesis :
7,8-dihydroneopterin 3'-triphosphate + H2O → 6-carboxy-5,6,7,8-tetrahydropterin + PPPi + acetaldehyde + 2 H+

threonine degradation IV :
L-threonine → acetaldehyde + glycine

Not in pathways:
1-ethyladenine + 2-oxoglutarate + oxygen → adenine + CO2 + acetaldehyde + succinate

two-component alkanesulfonate monooxygenase :
an alkanesulfonate + FMNH2 + oxygen → an aldehyde + sulfite + FMN + H2O + 2 H+


an aliphatic amine[periplasmic space] + H2O[periplasmic space] + oxygen[periplasmic space]an aldehyde[periplasmic space] + ammonium[periplasmic space] + hydrogen peroxide[periplasmic space]
a primary amine[periplasmic space] + H2O[periplasmic space] + oxygen[periplasmic space]an aldehyde[periplasmic space] + ammonium[periplasmic space] + hydrogen peroxide[periplasmic space]

Reactions known to both consume and produce the compound:

2'-deoxy-α-D-ribose 1-phosphate degradation :
2-deoxy-D-ribose 5-phosphate ↔ acetaldehyde + D-glyceraldehyde 3-phosphate
acetaldehyde + coenzyme A + NAD+ ↔ acetyl-CoA + NADH + H+

2-oxopentenoate degradation :
4-hydroxy-2-oxopentanoate ↔ acetaldehyde + pyruvate
acetaldehyde + coenzyme A + NAD+ ↔ acetyl-CoA + NADH + H+

ethanol degradation I :
ethanol + NAD+acetaldehyde + NADH + H+
acetaldehyde + coenzyme A + NAD+ ↔ acetyl-CoA + NADH + H+

mixed acid fermentation :
ethanol + NAD+acetaldehyde + NADH + H+
acetaldehyde + coenzyme A + NAD+ ↔ acetyl-CoA + NADH + H+

threonine degradation IV :
acetaldehyde + coenzyme A + NAD+ ↔ acetyl-CoA + NADH + H+

Not in pathways:
L-allo-threonine ↔ glycine + acetaldehyde
DL-allothreonine ↔ acetaldehyde + glycine


a primary alcohol + NAD+an aldehyde + NADH + H+

In Reactions of unknown directionality:

Not in pathways:
an aldehyde[periplasmic space] + FAD[periplasmic space] + H2O[periplasmic space] = a carboxylate[periplasmic space] + FADH2[periplasmic space]
an alcohol + NADP+ = an aldehyde + NADPH + H+

Enzymes inhibited by acetaldehyde, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: betaine aldehyde dehydrogenase [Falkenberg90] , 2-keto-4-hydroxyglutarate aldolase


References

Falkenberg90: Falkenberg P, Strom AR (1990). "Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli." Biochim Biophys Acta 1990;1034(3);253-9. PMID: 2194570


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc14.