Escherichia coli K-12 substr. MG1655 Compound: acetyl phosphate

Synonyms: acetyl-P

Chemical Formula: C2H3O5P

Molecular Weight: 138.02 Daltons

Monoisotopic Molecular Weight: 139.987459781 Daltons

acetyl phosphate compound structure

SMILES: CC(OP([O-])(=O)[O-])=O

InChI: InChI=1S/C2H5O5P/c1-2(3)7-8(4,5)6/h1H3,(H2,4,5,6)/p-2


Unification Links: CAS:19926-71-7, ChEBI:22191, ChemSpider:3394205, HMDB:HMDB01494, IAF1260:34318, KEGG:C00227, PubChem:4183249, UMBBD-Compounds:c0049

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -303.08

Reactions known to both consume and produce the compound:

acetate formation from acetyl-CoA I :
acetate + ATP ↔ acetyl phosphate + ADP
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

mixed acid fermentation :
acetate + ATP ↔ acetyl phosphate + ADP
acetyl-CoA + phosphate ↔ acetyl phosphate + coenzyme A

In Reactions of unknown directionality:

Not in pathways:
regulator of RpoS + acetyl phosphate = RssB-P + acetate

Enzymes activated by acetyl phosphate, sorted by the type of activation, are:

Activator (Mechanism unknown) of: malate dehydrogenase [Bologna07]

Enzymes inhibited by acetyl phosphate, sorted by the type of inhibition, are:

Inhibitor (Mechanism unknown) of: thiamine phosphate synthase [Kayama73, Kawasaki79, Comment 1]

This compound has been characterized as an alternative substrate of the following enzymes: phosphoglycolate phosphatase, fructose 1,6-bisphosphatase


Bologna07: Bologna FP, Andreo CS, Drincovich MF (2007). "Escherichia coli malic enzymes: two isoforms with substantial differences in kinetic properties, metabolic regulation, and structure." J Bacteriol 189(16);5937-46. PMID: 17557829

Kawasaki79: Kawasaki T (1979). "Thiamine phosphate pyrophosphorylase." Methods Enzymol 1979;62;69-73. PMID: 374983

Kayama73: Kayama Y, Kawasaki T (1973). "Purification and properties of thiaminephosphate pyrophosphorylase of Escherichia coli." Arch Biochem Biophys 1973;158(1);242-8. PMID: 4580841

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC14B.