Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

Escherichia coli K-12 substr. MG1655 Compound: arsenate

Synonyms: inorganic arsenate, orthoarsenate, AsO43-

Superclasses: an ion an anion

Chemical Formula: HO4As

Molecular Weight: 139.93 Daltons

Monoisotopic Molecular Weight: 141.92472998469998 Daltons

SMILES: [As](=O)(O)([O-])[O-]

InChI: InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5)/p-2

InChIKey: InChIKey=DJHGAFSJWGLOIV-UHFFFAOYSA-L

Unification Links: CAS:7778-39-4 , ChEBI:48597 , ChemSpider:228 , HMDB:HMDB12190 , IAF1260:37686 , KEGG:C01478 , PubChem:233

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -139.9

Reactions known to both consume and produce the compound:

arsenate detoxification II (glutaredoxin) :
arsenate + a reduced glutaredoxin + H+ ↔ arsenite + an oxidized glutaredoxin + H2O

In Transport reactions:
ATP + arsenate[cytosol] + H2O → ADP + arsenate[periplasmic space] + phosphate + H+ ,
arsenate[periplasmic space] + H+[periplasmic space]arsenate[cytosol] + H+[cytosol]

Enzymes activated by arsenate, sorted by the type of activation, are:

Activator (Mechanism unknown) of: glyceraldehyde 3-phosphate dehydrogenase [Zhao95] , glutamine synthetase deadenylase [Shapiro69]

Enzymes inhibited by arsenate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: alkaline phosphatase [Sowadski85] , transport of phosphate [Willsky80] , alkaline phosphatase [Sowadski85]

Inhibitor (Mechanism unknown) of: methylglyoxal synthase [Hopper72, Comment 1]


References

Hopper72: Hopper DJ, Cooper RA (1972). "The purification and properties of Escherichia coli methylglyoxal synthase." Biochem J 1972;128(2);321-9. PMID: 4563643

Shapiro69: Shapiro BM (1969). "The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements." Biochemistry 8(2);659-70. PMID: 4893578

Sowadski85: Sowadski JM, Handschumacher MD, Murthy HM, Foster BA, Wyckoff HW (1985). "Refined structure of alkaline phosphatase from Escherichia coli at 2.8 A resolution." J Mol Biol 1985;186(2);417-33. PMID: 3910843

Willsky80: Willsky GR, Malamy MH (1980). "Effect of arsenate on inorganic phosphate transport in Escherichia coli." J Bacteriol 144(1);366-74. PMID: 6998959

Zhao95: Zhao G, Pease AJ, Bharani N, Winkler ME (1995). "Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis." J Bacteriol 1995;177(10);2804-12. PMID: 7751290


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc11.