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Metabolic Modeling Tutorial
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Escherichia coli K-12 substr. MG1655 Compound: arsenate

Synonyms: inorganic arsenate, orthoarsenate, AsO43-

Superclasses: an ion an anion

Chemical Formula: HO4As

Molecular Weight: 139.93 Daltons

Monoisotopic Molecular Weight: 141.92472998469998 Daltons

SMILES: [As](=O)(O)([O-])[O-]

InChI: InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5)/p-2

InChIKey: InChIKey=DJHGAFSJWGLOIV-UHFFFAOYSA-L

Unification Links: CAS:7778-39-4 , ChEBI:48597 , ChemSpider:228 , HMDB:HMDB12190 , IAF1260:37686 , KEGG:C01478 , PubChem:233

Standard Gibbs Free Energy of Change Formation (ΔfG in kcal/mol): -139.9

Reactions known to both consume and produce the compound:

arsenate detoxification II (glutaredoxin) :
arsenate + a reduced glutaredoxin + H+ ↔ arsenite + an oxidized glutaredoxin + H2O

In Transport reactions:
ATP + arsenate[cytosol] + H2O → ADP + arsenate[periplasmic space] + phosphate + H+ ,
arsenate[periplasmic space] + H+[periplasmic space]arsenate[cytosol] + H+[cytosol]

Enzymes activated by arsenate, sorted by the type of activation, are:

Activator (Mechanism unknown) of: glyceraldehyde 3-phosphate dehydrogenase [Zhao95] , glutamine synthetase deadenylase [Shapiro69]

Enzymes inhibited by arsenate, sorted by the type of inhibition, are:

Inhibitor (Competitive) of: alkaline phosphatase [Sowadski85] , transport of phosphate [Willsky80] , alkaline phosphatase [Sowadski85]

Inhibitor (Mechanism unknown) of: methylglyoxal synthase [Hopper72, Comment 1]


References

Hopper72: Hopper DJ, Cooper RA (1972). "The purification and properties of Escherichia coli methylglyoxal synthase." Biochem J 1972;128(2);321-9. PMID: 4563643

Shapiro69: Shapiro BM (1969). "The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements." Biochemistry 8(2);659-70. PMID: 4893578

Sowadski85: Sowadski JM, Handschumacher MD, Murthy HM, Foster BA, Wyckoff HW (1985). "Refined structure of alkaline phosphatase from Escherichia coli at 2.8 A resolution." J Mol Biol 1985;186(2);417-33. PMID: 3910843

Willsky80: Willsky GR, Malamy MH (1980). "Effect of arsenate on inorganic phosphate transport in Escherichia coli." J Bacteriol 144(1);366-74. PMID: 6998959

Zhao95: Zhao G, Pease AJ, Bharani N, Winkler ME (1995). "Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis." J Bacteriol 1995;177(10);2804-12. PMID: 7751290


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Please cite the following article in publications resulting from the use of EcoCyc: Nucleic Acids Research 41:D605-12 2013
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc11.